Comparison of pure inositol hexaphosphate and high-bran diet in the prevention of DMBA-induced rat mammary carcinogenesis

• Published in: Nutrition and cancer Vol. 28; no. 1; p. 7
• Main Authors: Vucenik, I, Yang, G.Y, Shamsuddin, A.M
• Format: Journal Article
• Language: English
• Published: United States 1997
• Subjects: 9,10-Dimethyl-1,2-benzanthracene; ACIDE PHYTIQUE; ACIDO FITICO; ANIMAL MODELS; Animals; BENIGN COURSE; BLOOD SERUM; BODY WEIGHT; BRAN; BREAKFAST CEREALS; BREAST CANCER; CALCIO; CALCIUM; Carcinogens; CEREALE POUR PETIT DEJEUNER; CEREALES PARA DESAYUNO; CINC; CONTENIDO MINERAL; CONTROL DE ENFERMEDADES; CONTROLE DE MALADIES; DIET; DIETA; Dietary Fiber - administration & dosage; Dietary Fiber - therapeutic use; DISEASE CONTROL; DISEASE PREVENTION; DOSAGE EFFECTS; Drinking; EFECTOS DE DOSIFICACION; EFFET DOSE; ENFERMEDADES GLANDULAS MAMARIAS; EVOLUTION MALIGNE; EXPERIMENTACION; EXPERIMENTATION; Female; FER; FOOD INTAKE; GAIN DE POIDS; GANANCIA DE PESO; HIERRO; INCIDENCE; INGESTION DE ALIMENTOS; INHIBICION; INHIBITION; IRON; MAGNESIO; MAGNESIUM; MALADIE DES GLANDES MAMMAIRES; MALIGNANT COURSE; MAMMARY GLAND DISEASES; Mammary Neoplasms, Experimental - chemically induced; Mammary Neoplasms, Experimental - pathology; Mammary Neoplasms, Experimental - prevention & control; MINERAL CONTENT; Minerals - blood; MODELE ANIMAL; MODELOS ANIMALES; NEOPLASMAS; NEOPLASME; NEOPLASMS; PATHOGENESE; PATHOGENESIS; PATOGENESIS; PESO CORPORAL; PHYTIC ACID; Phytic Acid - administration & dosage; Phytic Acid - adverse effects; Phytic Acid - therapeutic use; POIDS CORPOREL; PRISE ALIMENTAIRE (HOMME); PROCESO MALIGNO; RAT; RATA; RATS; Rats, Sprague-Dawley; REGIME ALIMENTAIRE; SALVADO; SERUM SANGUIN; SON; SUERO SANGUINEO; TENEUR EN ELEMENTS MINERAUX; TUMOR MULTIPLICITY; WEIGHT GAIN; ZINC
• ISSN: 0163-5581; 1532-7914
• DOI: 10.1080/01635589709514546

Inositol hexaphosphate (IP6), abundant in cereals and legumes, has been demonstrated to be a promising anticancer agent in different in vivo and in vitro models. Because IP6 is particularly abundant in the bran part of certain mature seeds such as wheat, we investigated whether a high-fiber bran diet containing high IP6 shows a dose-response inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary carcinogenesis. Starting at two weeks before DMBA intubation, rats were divided into five groups and fed AIN-76A diet only or AIN-76A diet containing 5%, 10%, or 20% Kelloggs' All Bran; the fifth group received 0.4% IP6 given in drinking water, an amount equivalent to the IP6 content in 20% bran. After carcinogen administration, the rats remained on these regimens for 29 weeks. Compared with the carcinogen control, at 29th week, tumor incidence was reduced by 16.7%, 14.6%, and 11.4% in rats fed 5%, 10%, and 20% bran, respectively (not statistically significant). However, rats given 0.4% IP6 in drinking water, equivalent to that in 20% bran, had a 33.5% reduction in tumor incidence (p 0.02) and 48.8% fewer tumors (p 0.03). These data show that supplemental dietary fiber in the form of bran exhibited a very modest, statistically nonsignificant inhibitory effect, which was also not dose dependent. In contrast, animals given IP6 showed significant reduction in tumor number, incidence, and multiplicity. Thus IP6, an active substance responsible for cereal's beneficial anticancer effect, is clearly more effective than 20% bran in the diet. In practical terms, intake of IP6 may be a more pragmatic approach than gorging enormous quantities of fiber for cancer prophylaxis