The Landscape of Interactions between Hypoxia-Inducible Factors and Reactive Oxygen Species in the Gastrointestinal Tract

• Published in: Oxidative medicine and cellular longevity Vol. 2021; no. 1; p. 8893663
• Main Authors: Shao, Yirui, Wang, Kexing, Xiong, Xia, Liu, Hongnan, Zhou, Jian, Zou, Lijun, Qi, Ming, Liu, Gang, Huang, Ruilin, Tan, Zhiliang, Yin, Yulong
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2021; Hindawi Limited
• Subjects: Apoptosis; Cell adhesion & migration; Gastrointestinal diseases; Growth factors; Homeostasis; Hypoxia; Inflammatory bowel disease; Kinases; Lipids; Metabolism; Oxidative stress; Permeability; Proteins; Review
• ISSN: 1942-0900; 1942-0994
• DOI: 10.1155/2021/8893663

The gastrointestinal tract (GT) is the major organ involved in digestion, absorption, and immunity, which is prone to oxidative destruction by high levels of reactive oxygen species (ROS) from luminal oxidants, such as food, drugs, and pathogens. Excessive ROS will lead to oxidative stresses and disrupt essential biomolecules, which also act as cellular signaling molecules in response to growth factors, hormones, and oxygen tension changes. Hypoxia-inducible factors (HIFs) are critical regulators mediating responses to cellular oxygen tension changes, which are also involved in energy metabolism, immunity, renewal, and microbial homeostasis in the GT. This review discusses interactions between HIF (mainly HIF-1α) and ROS and relevant diseases in the GT combined with our lab’s work. It might help to develop new therapies for gastrointestinal diseases associated with ROS and HIF-1α.