Effects of central administration of arginine-vasopressin on aversive memory retrieval

This study examined whether arginine-vasopressin (A-VP), given before the test would produce an improved retrieval of aversive memory, in the same way as pre-exposure to inescapable footshocks, in rats. For this purpose animals conditioned in a T-maze with appetitive (10% sucrose) and aversive (2.0...

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Published inBrain research Vol. 699; no. 2; pp. 293 - 296
Main Authors Kumar, K.B., Karanth, K.S.
Format Journal Article
LanguageEnglish
Published London Elsevier B.V 20.11.1995
Amsterdam Elsevier
New York, NY
Subjects
Animals
Arginine Vasopressin - pharmacology
Arginine-vasopressin
Aversive memory
Avoidance Learning - drug effects
Behavioral psychophysiology
Biological and medical sciences
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Learned helplessness
Male
Memory - drug effects
Neurotransmission and behavior
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Wistar
Arginine-vasopressin
Learned helplessness
Aversive memory
Vertebrata
Mammalia
Acquisition process
Rat
Animal
Memory
Rodentia
Anticonvulsant
Conditioned aversion
Neuropeptide
Vasopressin
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Summary:This study examined whether arginine-vasopressin (A-VP), given before the test would produce an improved retrieval of aversive memory, in the same way as pre-exposure to inescapable footshocks, in rats. For this purpose animals conditioned in a T-maze with appetitive (10% sucrose) and aversive (2.0 mA footshock) events were administered (intracerebroventricular) a single dose of 2.5, 5, 10 or 20 ng/rat of A-VP, 20-min before testing. In the retention test conducted with the same training apparatus 72 h after conditioning, the peptide treated rats showed a dose-dependent increase in latencies to enter the previously shocked goalarm, with the absence of such a difference in responding to the non-shocked goalarm. This differential response was not observed in saline treated rats. This effect of peptide on memory retrieval was similar to that seen following inescapable footshock in rats. These results suggest the possible involvement of central vasopressinergic mechanisms in the differential enhancement of memory of helplessness condition.
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ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(95)00921-C