Genetic Polymorphism of Matrix Metalloproteinase-9 and Susceptibility to Myocardial Infarction: A Meta-Analysis

Objective. Current findings on the association between MMP-9 rs3918242 and susceptibility to myocardial infarction (MI) are inconsistent, and their definite relationship is discussed in this meta-analysis. Methods. Eligible literatures reporting MMP-9 rs3918242 and susceptibility to MI were searched...

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Published inDisease markers Vol. 2022; pp. 1 - 8
Main Authors Feng, Beili, Li, Hengdong
Format Journal Article
LanguageEnglish
Published United States Hindawi 2022
John Wiley & Sons, Inc
Subjects
Alleles
Angina pectoris
Asian people
Atherosclerosis
Cardiovascular disease
Coronary vessels
Diabetes
Enzymes
Extracellular matrix
Gelatinase B
Gene polymorphism
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Heart attacks
Hospitals
Humans
Hypoxia
Matrix metalloproteinase
Matrix Metalloproteinase 9 - genetics
Matrix metalloproteinases
Meta-analysis
Metalloproteinase
Mutation
Myocardial infarction
Myocardial Infarction - diagnosis
Myocardial Infarction - genetics
Polymorphism
Polymorphism, Single Nucleotide
Population
Risk Factors
Susceptibility
White people
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Summary:Objective. Current findings on the association between MMP-9 rs3918242 and susceptibility to myocardial infarction (MI) are inconsistent, and their definite relationship is discussed in this meta-analysis. Methods. Eligible literatures reporting MMP-9 rs3918242 and susceptibility to MI were searched in PubMed, Cochrane Library, CNRI, and VIP using keywords such as “MMP-9”, “matrix metallopeptidase-9” and “myocardial infarction”, “acute myocardial infarction”, “AMI”, and “polymorphism”. Data from eligible literatures were extracted for calculating OR and corresponding 95% CI using RevMan 5.3 and STATA12.0. Results. Ten independent literatures reporting MMP-9 rs3918242 and susceptibility to MI were enrolled. Compared with subjects carrying CT&TT genotype of MMP-9 rs3918242, susceptibility to MI was lower in those carrying CC genotype (OR=1.49, 95%CI=1.19–1.86, P=0.0004). Such a significance was observed in the overdominant (OR=1.27, 95%CI=1.14–1.41, P<0.0001) and allele genetic models (OR=1.43, 95%CI=1.17–1.74, P=0.0005) as well. This finding was also valid in the Asian population. Conclusions. Mutation on MMP-9 rs3918242 has a potential relevance with susceptibility to MI.
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Academic Editor: Simona Pichini
ISSN:0278-0240
1875-8630
1875-8630
DOI:10.1155/2022/5507153