Pathogenic Characterization of a Porcine Circovirus Type 3 Isolate from Heilongjiang, China

• Published in: Disease markers Vol. 2021; pp. 9434944 - 8
• Main Authors: Wang, Menghang, Yu, Ying, Wu, Jianan, Meng, Fandan, Tang, Yandong, Wang, Shujie, Wang, Yu, Cui, Hongliang, He, Xijun, Tu, Yabin, Wang, Gang, Cai, Xuehui
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2021; Hindawi Limited
• Subjects: Amino acids; Animals; Antibodies, Viral - metabolism; Asymptomatic Infections; Biomarkers - metabolism; Brain; China; Circoviridae Infections - immunology; Circoviridae Infections - pathology; Circoviridae Infections - veterinary; Circoviridae Infections - virology; Circovirus - genetics; Circovirus - immunology; Circovirus - isolation & purification; Circovirus - pathogenicity; Colostrum; Experiments; Genome, Viral; Genomes; Hogs; IgG antibody; Immunoglobulin G; Inoculation; Kidneys; Lungs; Lymph nodes; Lymphatic system; Organs; Pathogenicity; Pathogens; Phylogenetics; Proteins; Random Allocation; Spleen; Sus scrofa; Swine; Swine Diseases - immunology; Swine Diseases - pathology; Swine Diseases - virology; Tonsil; Viral Load; Viral Proteins - genetics; Viral Proteins - immunology; China; United States > US
• ISSN: 0278-0240; 1875-8630
• DOI: 10.1155/2021/9434944

The clinical outcome of porcine circovirus 3 (PCV3) infection is still controversial. Herein, a novel PCV3 isolate (PCV3-China/DB-1/2017) with the molecular characterization of 24A and 27K in the Cap protein was used to inoculate three-week-old cesarean-derived, colostrum-deprived piglets. The nine PCV3 DB-1 inoculated piglets exhibited no obvious clinical symptoms or macroscopic lesions. PCV3 displayed a broad histotropism, including the heart, liver, spleen, lung, kidney, brain, lymph nodes, and tonsil, and the lungs and lymph nodes contained a higher quantity of viral genomes compared to that of the other organs. From 7 days after PCV3 DB-1 inoculation, the piglets showed obvious IgG antibody responses against PCV3 rCap-VLPs. The cumulative results demonstrated that PCV3 trend to low pathogenicity.