Prevalence of factor H Binding Protein sub-variants among Neisseria meningitidis in China

• Published in: Vaccine Vol. 35; no. 18; pp. 2343 - 2350
• Main Authors: Shi, Fenglin, Zhang, Aiyu, Zhu, Bingqing, Gao, Yuan, Xu, Li, Li, Yixing, Yin, Zundong, Li, Junhong, Xie, Na, Shao, Zhujun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 25.04.2017; Elsevier Limited
• Subjects: Agar; Agglutination; Allergy and Immunology; Amino acid sequence; Antigens; Antigens, Bacterial - classification; Antigens, Bacterial - genetics; Approximation; Atmosphere; Bacteria; Bacterial Proteins - classification; Bacterial Proteins - genetics; Binding; Biochemical characteristics; Biochemistry; Blood; Blood culture; Carbon dioxide; Carrier State - microbiology; Cell adhesion; Cell adhesion & migration; Cell adhesion molecules; Cell culture; Centrifugation; Cerebrospinal fluid; Chin; China; Computer programs; Disease control; Disease prevention; Epidemics; Factor H Binding Protein; Gene Frequency; Genetic Variation; Genomes; Genotype; Human performance; Humans; Immunogenicity; Incidence; Investigations; Membrane proteins; Membrane vesicles; Meningitis; Meningococcal Infections - microbiology; Microorganisms; Milk; Molecular Typing; Multilocus sequence typing; Neisseria meningitidis; Neisseria meningitidis, Serogroup B - genetics; Neisseria meningitidis, Serogroup B - isolation & purification; Peptides; Polymorphism; Populations; Proteins; Saline water; Sun; Tables (data); Vaccine; Vaccine development; Vaccines; China; Factor H Binding Protein; Neisseria meningitidis; Vaccine
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2017.03.057

Highlights • 1012 N. meningitidis strains investigated were collected over a period of 60 years. • Various serogroups and clonal complexes of meningococci were included in this study. • MenB isolates in China harbored fHbp gene mainly encoding variant 2 FHbp.