Effect of Neonatal Epileptic Attacks on the Activity of Neocortical Neurons

Using the flurothyl model of neonatal epilepsy, we found that the sensitivity to a proepileptic agent (blocker of inhibitory synaptic transmission, bicuculline) is higher in slices of the somatosensory cortex of 80- to 90-dayold rats subjected preliminarily, within the neonatal period, to induction...

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Published inNeurophysiology (New York) Vol. 43; no. 3; pp. 227 - 228
Main Authors Isaev, D. S., Isaeva, E. V., Savrasova, A. V., Holmes, G. L.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.11.2011
Springer
Springer Nature B.V
Subjects
Analysis
Babies
Bicuculline
Biomedical and Life Sciences
Biomedicine
Brain
Brain slice preparation
Cortex
Cortex (somatosensory)
Epilepsy
flurothyl
Neonates
Neurobiology
Neurons
Neurosciences
Seizures
Seizures (Medicine)
Synaptic transmission
neonatal epileptic attacks
somatosensory cortex
flurothyl model
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Summary:Using the flurothyl model of neonatal epilepsy, we found that the sensitivity to a proepileptic agent (blocker of inhibitory synaptic transmission, bicuculline) is higher in slices of the somatosensory cortex of 80- to 90-dayold rats subjected preliminarily, within the neonatal period, to induction of epileptic attacks, as compared with those from control rats. The interictal-like seizure activity (extracellular recording from layer 2 of the neocortex) evoked by bicuculline applications developed in these cases with a noticeably greater probability.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0090-2977
1573-9007
DOI:10.1007/s11062-011-9209-1