Acupoint Injection for Alleviating Side Effects of Chemotherapy in People with Cancer: A Systematic Review and Meta-Analysis

Objective. This study aimed to investigate the efficacy of acupoint injection for alleviating side effects of chemotherapy in people with cancer. Methods. PubMed, EMBASE, Cochrane library databases, CNKI, VIP, WanFang Date, and CBM were searched for randomized controlled trials (RCTs) from inception...

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Published inEvidence-based complementary and alternative medicine Vol. 2021; pp. 9974315 - 8
Main Authors Yang, Yulan, Su, Hairong, Wen, Jian, Hong, Jianyun
Format Journal Article
LanguageEnglish
Published United States Hindawi 2021
Hindawi Limited
Subjects
Acupuncture
Alternative medicine
Bias
Bone marrow
Cancer
Cancer therapies
Chemotherapy
Granulocytes
Injection
Lung cancer
Meta-analysis
Nausea
Quality of life
Review
Side effects
Software
Statistical analysis
Systematic review
Thrombocytopenia
Vomiting
China
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Summary:Objective. This study aimed to investigate the efficacy of acupoint injection for alleviating side effects of chemotherapy in people with cancer. Methods. PubMed, EMBASE, Cochrane library databases, CNKI, VIP, WanFang Date, and CBM were searched for randomized controlled trials (RCTs) from inception through December 28, 2020. This meta-analysis was performed using Review Manager 5.3. Results. A total of 8 RCTs including 557 participants were eligible and included in the meta-analysis. The selected RCTs studied acupoint injection for alleviating side effects of chemotherapy in people with cancer. Statistically significant improvements were observed for the incidence of nausea and vomiting (RR = 0.39; 95% CI 0.26, 0.58; P < 0.00001), the number of leukocyte (MD = 1.89; 95%CI 0.74, 3.03; P = 0.001), and the number of platelet (MD = 28.82; 95%CI 19.33, 38.30; P < 0.00001). Two of these studies suggested that acupoint injection can also reduce some other adverse reactions, which showed a statistical difference (RR = 0.29; 95% CI 0.11, 0.75; P = 0.01). Conclusion. The analysis indicated that acupoint injection can alleviate side effects of chemotherapy in people with cancer. However, due to the high risk of bias and small sample size in the included studies, the results need to be further confirmed by further large, rigorously designed trials.
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Academic Editor: Amin Tamadon
ISSN:1741-427X
1741-4288
DOI:10.1155/2021/9974315