Feasibility of a randomized trial of a high-vegetable diet to prevent breast cancer recurrence

• Published in: Nutrition and cancer Vol. 28; no. 3; p. 282
• Main Authors: Pierce, J.P, Faerber, S, Wright, F.A, Newman, V, Flatt, S.W, Kealey, S, Rock, C.L, Hryniuk, W, Greenberg, E.R
• Format: Journal Article
• Language: English
• Published: United States 1997
• Subjects: ALPHA-CAROTENE; BETA-CAROTENE; BETA-CRYPTOXANTHIN; BIOLOGICAL INDICATORS; Biomarkers; Breast Neoplasms - prevention & control; CAROTENOIDE; CAROTENOIDES; CAROTENOIDS; Carotenoids - blood; CLINICAL TRIALS; CONTROL DE ENFERMEDADES; CONTROLE DE MALADIES; CORPS GRAS; DIET; DIET COUNSELING; DIETA; Dietary Fats - administration & dosage; Dietary Fiber - administration & dosage; DIETARY FIBRES; DISEASE CONTROL; DISEASE PREVENTION; ENSAYOS CLINICOS; ESSAI CLINIQUE; ESTUDIOS DE FACTIBILIDAD; ETUDE DE FAISABILITE; FATS; FEASIBILITY STUDIES; Female; FEMME; FIBRA DE LA DIETA; FIBRE ALIMENTAIRE; FOOD INTAKE; Fruit; GRASAS; HORTALIZAS; HUMAN NUTRITION; Humans; INDICATOR ORGANISMS; INGESTION DE ALIMENTOS; LEGUME; LICOPENO; LONGITUDINAL STUDIES; LYCOPENE; MUJERES; Neoplasm Recurrence, Local - prevention & control; NEOPLASMAS; NEOPLASME; NEOPLASMS; NUTRICION HUMANA; NUTRITION HUMAINE; ORGANISME INDICATEUR; ORGANISMOS INDICADORES; PATIENT COMPLIANCE; PRISE ALIMENTAIRE (HOMME); Randomized Controlled Trials as Topic; REGIME ALIMENTAIRE; TELECOMMUNICATION; TELECOMMUNICATIONS; TELECOMUNICACIONES; TELEPHONES; VEGETABLES; WOMEN; XANTHOPHYLLE; XANTHOPHYLLS; XANTOFILAS
• ISSN: 0163-5581; 1532-7914
• DOI: 10.1080/01635589709514589

Epidemiologic evidence supports the concept that diet influences risk for breast cancer and suggests that prognosis after the diagnosis of breast cancer may also be related to modifiable nutritional factors. The purpose of this study was to investigate the feasibility of a randomized trial of a high-vegetable, reduced-fat, and increased-fiber diet intervention to reduce risk for recurrence among breast cancer survivors. This major change in dietary pattern was promoted through intensive telephone counseling. Participants were 93 women who had been diagnosed with breast cancer (stages I, II, and IIIA) within the previous four years and who had completed their initial treatment. We assessed adherence to the study diet using repeated 24-hour dietary recalls at 6 and 12 months and measurement of circulating carotenoid concentrations. Six months after randomization, the intervention group had significantly increased their mean intake of vegetables (+4.6 servings/day), fruit (+0.7 servings/day), and fiber (+6.4 g/1,000 kcal) and significantly reduced their intake of dietary fat (-9.9% of energy) compared with the control group. Circulating concentrations of carotenoids also increased in the intervention group. These changes persisted at the 12-month visit. Results of this study demonstrate that telephone counseling can be a useful approach in diet intervention and that breast cancer survivors can adopt and maintain a high-vegetable, reduced-fat dietary pattern