Gastrointestinal syndrome encountered during a train voyage to high altitudes: A 14-day survey of 69 passengers in China

• Published in: Travel medicine and infectious disease Vol. 59; p. 102718
• Main Authors: Chen, Yihui, Tang, Xiaoqi, Zeng, Xiong, Han, Ben, Xie, Huichao, Wang, Wei, Sun, Lihua, Hu, Mingdong, Gao, Yuqi, Xiao, Weidong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.05.2024; Elsevier Limited; Elsevier
• Subjects: Abdomen; Acute mountain sickness; Adolescent; Adult; Aged; Alcohols; Altitude; Altitude Sickness - epidemiology; China - epidemiology; Constipation; Diarrhea; Female; Gastrointestinal Diseases - epidemiology; Gastrointestinal Diseases - etiology; Gender; Headaches; High altitude; Humans; Hyperactivity; Incidence; Indoor air quality; Investigations; Male; Middle Aged; Prevalence; Prevention; Questionnaires; Railroads; Risk Factors; Surveys and Questionnaires; Symptoms; Trains; Travel; Young Adult; China; Acute mountain sickness; High altitude
• ISSN: 1477-8939; 1873-0442
• DOI: 10.1016/j.tmaid.2024.102718

The diagnosis and evaluation of the severity of acute mountain sickness (AMS) continue to be problematic due to a lack of consensus on the inclusion of symptoms in a scoring system. Recent investigations highlight the significance of gastrointestinal symptoms in identifying this condition. However, the specific gastrointestinal symptoms associated with AMS have not been thoroughly elucidated in previous studies, and the underlying risk factors remain inadequately comprehended. This study aimed to investigate the characteristics, trends, and risk factors related to gastrointestinal symptoms encountered during train travel to high altitude. A total of 69 passengers, specifically all with medical backgrounds, were surveyed 6 times over a period of 14 days. The daily incidence of abdominal discomfort was higher than non-gastrointestinal symptoms within 14 days. Gastrointestinal symptoms demonstrated a greater prevalence, longer duration, and increased risk compared to non-gastrointestinal symptoms, such as headaches. The symptoms of abdominal distension and bowel sound hyperaction were found to be prevalent and persistent among patients diagnosed with AMS, exhibiting a high incidence rate. Gender, age, body mass index (BMI), smoking habits, and alcohol consumption were identified as risk factors associated with the occurrence and duration of gastrointestinal symptoms. This study suggests that gastrointestinal symptoms are more common and persistent when traveling to the plateau by train. These symptoms should be taken into consideration in the further diagnosis and prevention of AMS. Therefore, this study provides a significant theoretical foundation for the prevention and treatment of AMS.