Potential application value of pigment epithelium-derived factor in sensorineural hearing loss

The inner ear is a complex and precise auditory perception system responsible for receiving and converting sound signals into neural signals, enabling us to perceive and understand sound. However, the occurrence and development of inner ear diseases and auditory disorders, such as sensorineural hear...

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Published inFrontiers in neuroscience Vol. 17; p. 1302124
Main Authors Sun, Zihui, Li, Xiaoguang, Li, Guangfei, Xu, Ying, Meng, Jie, Meng, Wei, He, Shuangba
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 14.12.2023
Frontiers Media S.A
Subjects
Amino acids
Angiogenesis
Apoptosis
auditory function
Auditory perception
Cells
Cytokines
Ear diseases
Epithelium
Hearing loss
Hearing protection
Homeostasis
Inflammation
Inner ear
Kinases
Neurons
Neuroscience
Oxidative stress
Pigment epithelium-derived factor
pigment epithelium-derived factor (PEDF)
potential
Proteins
sensorineural hearing loss
signaling pathway
therapeutic prospects
Tumor necrosis factor-TNF
sensorineural hearing loss
auditory function
signaling pathway
therapeutic prospects
potential
pigment epithelium-derived factor (PEDF)
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Summary:The inner ear is a complex and precise auditory perception system responsible for receiving and converting sound signals into neural signals, enabling us to perceive and understand sound. However, the occurrence and development of inner ear diseases and auditory disorders, such as sensorineural hearing loss, remain a global problem. In recent years, there has been increasing research on the treatment of inner ear diseases and auditory regeneration. Among these treatments, pigment epithelium-derived factor (PEDF), as a multifunctional secretory protein, exhibits diverse biological activities and functions through various mechanisms, and has shown potential applications in the inner ear. This minireview comprehensively evaluates the performance of PEDF in sensorineural hearing loss in inner ear and its potential targets and therapeutic prospects.
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These authors have contributed equally to this work
Reviewed by: Wang Weilong, Tangdu Hospital, China; Haiying Sun, Huazhong University of Science and Technology, China
Edited by: Zuhong He, Wuhan University, China
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2023.1302124