Diarylalkanoids as Potent Tyrosinase Inhibitors from the Stems of Semecarpus caudata

From a CHCl3-soluble extract of the stems of Semecarpus caudata (Anacardiaceae), two new diarylalkanoids, semedienone (1) and semetrienone (2), were isolated. Their structures were elucidated based on NMR spectroscopic data interpretation. These compounds possess strong tyrosinase inhibitory activit...

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Published inEvidence-based complementary and alternative medicine Vol. 2021; pp. 8872920 - 8
Main Authors Dang, Phu H., Le, Tho H., Do, Truong N. V., Nguyen, Hai X., Nguyen, Mai T. T., Nguyen, Nhan T.
Format Journal Article
LanguageEnglish
Published United States Hindawi 2021
Hindawi Limited
Subjects
Acids
Alternative medicine
Amino acids
Binding sites
Chromatography
Ligands
NMR
Nuclear magnetic resonance
Peroxide
Semecarpus
Vietnam
Germany
Singapore
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Summary:From a CHCl3-soluble extract of the stems of Semecarpus caudata (Anacardiaceae), two new diarylalkanoids, semedienone (1) and semetrienone (2), were isolated. Their structures were elucidated based on NMR spectroscopic data interpretation. These compounds possess strong tyrosinase inhibitory activity with the IC50 values of 0.033 and 0.11 μM, respectively. Docking studies of 1 and 2 with oxy-tyrosinase were carried out to analyze their interactions. Accordingly, semedienone (1) showed good interactions with the peroxide group and amino acid residues. The biosynthesis of the isolated diarylalkanoids was proposed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Academic Editor: Siba shanak
ISSN:1741-427X
1741-4288
DOI:10.1155/2021/8872920