Insights into the Role of Oxidative Stress in Ovarian Cancer

• Published in: Oxidative medicine and cellular longevity Vol. 2021; no. 1; p. 8388258
• Main Authors: Ding, Dan-Ni, Xie, Liang-Zhen, Shen, Ying, Li, Jia, Guo, Ying, Fu, Yang, Liu, Fang-Yuan, Han, Feng-Juan
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2021; Hindawi Limited
• Subjects: Antioxidants; Apoptosis; Cancer therapies; Chemotherapy; Drug resistance; Female; Free radicals; Gene expression; Glucose; Humans; Kinases; Medical prognosis; Metabolism; Metabolites; Mutation; Nitric oxide; Ovarian cancer; Ovarian Neoplasms - physiopathology; Oxidative stress; Oxidative Stress - drug effects; Oxygen; Pathogenesis; Phosphatase; Proteins; Radiation; Review; Survival analysis; Transcription factors; Tumors
• ISSN: 1942-0900; 1942-0994
• DOI: 10.1155/2021/8388258

Oxidative stress (OS) arises when the body is subjected to harmful endogenous or exogenous factors that overwhelm the antioxidant system. There is increasing evidence that OS is involved in a number of diseases, including ovarian cancer (OC). OC is the most lethal gynecological malignancy, and risk factors include genetic factors, age, infertility, nulliparity, microbial infections, obesity, smoking, etc. OS can promote the proliferation, metastasis, and therapy resistance of OC, while high levels of OS have cytotoxic effects and induce apoptosis in OC cells. This review focuses on the relationship between OS and the development of OC from four aspects: genetic alterations, signaling pathways, transcription factors, and the tumor microenvironment. Furthermore, strategies to target aberrant OS in OC are summarized and discussed, with a view to providing new ideas for clinical treatment.