Results of genotoxicity testing of mazindol (degonan), lithium carbonicum (contemnol) and dropropizine (ditustat) in Chinese hamster V79 and human EUE cells

We studied inhibition of DNA synthesis, alkaline elution of DNA, cytotoxicity and occurrence of induced 6-thioguanine resistant mutants in mammalian cells, treated with mazindol, lithium carbonicum, and dropropizine, respectively, in the presence and in the absence of microsomal fraction S9. Among t...

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Published inMutation Research/Genetic Toxicology Vol. 169; no. 3; pp. 171 - 177
Main Authors Slameňová, D., Budayová, E., Gábelová, A., Morávková, A., Pániková, L.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.1986
Subjects
Animals
Benzo(a)pyrene - metabolism
Benzo(a)pyrene - pharmacology
Biotransformation
Cell Line
Cricetinae
DNA Replication - drug effects
Fibroblasts - drug effects
Humans
Indoles - pharmacology
Lithium - metabolism
Lithium - pharmacology
Lithium Carbonate
Lung
Male
Mazindol - metabolism
Mazindol - pharmacology
Microsomes, Liver - metabolism
Mutagenicity Tests
Propylene Glycols - metabolism
Propylene Glycols - pharmacology
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Summary:We studied inhibition of DNA synthesis, alkaline elution of DNA, cytotoxicity and occurrence of induced 6-thioguanine resistant mutants in mammalian cells, treated with mazindol, lithium carbonicum, and dropropizine, respectively, in the presence and in the absence of microsomal fraction S9. Among the above-mentioned clinically used drugs only dropropizine showed neither mutagenic nor clastogenic effects. Lithium carbonicum manifested a weak and mazindol a medium genotoxic response which was in both cases reduced in the presence of microsomal fraction S9.
ISSN:0165-1218
0027-5107
DOI:10.1016/0165-1218(86)90096-0