Recent developments in anxiety, stress, and depression

• Published in: Pharmacology, biochemistry and behavior Vol. 54; no. 1; pp. 3 - 12
• Main Author: File, Sandra E.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01.05.1996; Elsevier Science
• Subjects: Animal tests; Animals; Anxiety; Anxiety - metabolism; Anxiety - physiopathology; Anxiety - psychology; Biological and medical sciences; Depression; Depression - metabolism; Depression - physiopathology; Depression - psychology; Glucocorticoids; Humans; Immune function; Medical sciences; Neuropharmacology; Pharmacology. Drug treatments; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Stress; Stress, Psychological - metabolism; Stress, Psychological - physiopathology; Stress, Psychological - psychology; Depression; Anxiety; Immune function; Glucocorticoids; Stress; Animal tests; Mood disorder; Animal model; Psychotropic; Anxiety disorder; Review; Screening test; Biological activity; Tranquillizer; Animal; Antidepressant agent; 5-HT1A receptor
• ISSN: 0091-3057; 1873-5177
• DOI: 10.1016/0091-3057(95)02175-2

Recent research in the development, analysis, and pharmacology of animal tests of state anxiety is discussed, including the use of responses to predator odours, the role of learning in modifying the anxiety measured in the plus-maze, and the roles of cholinergic, NMDA, and dopaminergic systems. Developmental and genetic factors are considered with particular reference to the development of tests of trait anxiety. The roles of 5-HT 1A receptors in anxiety, depression, impulsivitity, and agonistic behaviours are discussed. Recent studies on the impacts of stress on neurotransmitter, endocrine, and immune systems and the interactions between these systems are discussed, with particular emphasis on their contributions to the development of pathologic states relevant to anxiety and depression.