The prognostic value of radiological and pathological lymph node status in patients with cervical cancer who underwent neoadjuvant chemotherapy and followed hysterectomy

• Published in: Scientific reports Vol. 14; no. 1; p. 2045
• Main Authors: Lou, Jianghua, Zhang, Xiaoxian, Liu, Jinjin, Dong, Linxiao, Wu, Qingxia, Yan, LiangLiang, Xu, Chunmiao, Wang, Meiyun
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 24.01.2024; Nature Publishing Group UK; Nature Portfolio
• Subjects: Cervical cancer; Chemotherapy; Female; Histology; Humans; Hysterectomy; Lymph nodes; Lymph Nodes - diagnostic imaging; Lymphatic system; Neoadjuvant Therapy; Prognosis; Radiation; Regression analysis; Retrospective Studies; Risk factors; Survival; Tumors; Uterine Cervical Neoplasms - diagnostic imaging; Uterine Cervical Neoplasms - drug therapy
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-49539-7

To investigate the prognostic value of lymph node status in patients with cervical cancer (CC) patients who underwent neoadjuvant chemotherapy (NACT) and followed hysterectomy. Patients in two referral centers were retrospectively analyzed. The baseline tumor size and radiological lymph node status (LNr) were evaluated on pre-NACT MRI. Tumor histology, differentiation and pathological lymph node status (LNp) were obtained from post-operative specimen. The log-rank test was used to compare survival between patient groups. Cox proportional hazards regression models were employed to estimate the hazard ratio (HR) of various factors with progression-free survival (PFS) and overall survival (OS). A total of 266 patients were included. Patients with 2018 FIGO IIIC showed worse PFS compared to those with FIGO IB-IIB (p < 0.001). The response rate in patients with LNp(-) was 64.1% (134/209), significantly higher than that of 45.6% (26/57) in patients with LNp( +) (p = 0.011). Multivariate Cox analysis identified the main independent predictors of PFS as LNp( +) (HR = 3.777; 95% CI 1.715-8.319), non-SCC (HR = 2.956; 95% CI 1.297-6.736), poor differentiation (HR = 2.370; 95% CI 1.130-4.970) and adjuvant radiation (HR = 3.266; 95% CI 1.183-9.019). The interaction between LNr and LNp regarding PFS were significant both for univariate and multivariate (P = 0.000171 and 1.5357e respectively). In patients with LNr( +), a significant difference in PFS was observed between patients with LNp(-) and LNp( +) (p = 0.0027). CC patients with FIGO 2018 stage IIIC who underwent NACT and followed hysterectomy had worse PFS compared to those with IB-IIB. LNp( +), non-SCC, poor differentiation and adjuvant radiation were independent risk factors for PFS. The adverse prognostic value of LNp( +) was more significant in patients with LNr( +).