Kinetic selection of polymeric guanosine architectures from dynamic supramolecular libraries

• Published in: Comptes rendus. Chimie Vol. 18; no. 9; pp. 960 - 965
• Main Authors: Meffre, Anca, Petit, Eddy, Cot, Didier, Barboiu, Mihail
• Format: Journal Article
• Language: English
• Published: ISSY-LES-MOULINEAUX Elsevier SAS 01.09.2015; Elsevier; Académie des sciences (Paris)
• Subjects: Chemical Sciences; Chemistry; Chemistry, Multidisciplinary; Constitutional materials; G-quadruplex; H-bonding; Hybrid polymers; Physical Sciences; Science & Technology; Self-assembly; Hybrid polymers; Constitutional materials; Self-assembly; G-quadruplex; H-bonding; HYBRID MATERIALS; CHEMISTRY
• ISSN: 1631-0748; 1878-1543
• DOI: 10.1016/j.crci.2015.03.019

We report the constitutional resolution and selection of the dynamic supramolecular guanosine systems by using a kinetically irreversible polymerization process. We report an original strategy to transcribe and to fix supramolecular guanosine architectures in self-organized polymers. In the first resolution step, the G-quartet and G-quadruplex architectures are pre-amplified in solution in the presence of K+ cations from a dynamic pool of ribbon-type or cyclic supramolecular architectures. Then in a second selection polymerization step, the G-quadruplex is kinetically fixed in a covalent polymethacrylate network via an irreversible amplification step. Both supramolecular and polymeric components mutually (synergistically) adapt their spatial constitution during simultaneous (collective) formation of micrometric self-organized hybrid domains. This contributes to the high level of adaptability and correlativity of the self-organization of the supramolecular G-quadruplexes and of the polymeric systems. Biomimetic-type hybrid systems can be generated by using this strategy.