Enhancement of the Immunostimulatory Activity of 1,25-Dihydroxyvitamin D3-Differentiated HL60 Cells with an Arabinoxylan from Wheat Bran

We found that a wheat bran arabinoxylan (WBA) activates the phagocytosis of 1,25-dihydroxyvitamin D3-differentiated HL60 cells; however, its mechanism was unknown. Hence, we investigated the molecular mechanism involved in the WBA-induced increase of immunostimulating activity using inhibitors. The...

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Bibliographic Details
Published inFood Science and Technology Research Vol. 18; no. 3; pp. 481 - 484
Main Authors MONOBE, Manami, KATAYANAGI, Yuki, MAEDA-YAMAMOTO, Mari, HIRAMOTO, Shigeru
Format Journal Article
LanguageEnglish
Published Tsukuba Japanese Society for Food Science and Technology 2012
Japan Science and Technology Agency
Subjects
caspase-1
cathepsin B
IL-1β
phagocytosis
wheat bran arabinoxylan
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Summary:We found that a wheat bran arabinoxylan (WBA) activates the phagocytosis of 1,25-dihydroxyvitamin D3-differentiated HL60 cells; however, its mechanism was unknown. Hence, we investigated the molecular mechanism involved in the WBA-induced increase of immunostimulating activity using inhibitors. The results indicated that the WBA-induced increases in phagocytic activity and IL-1β production were inhibited by cathepsin B and caspase-1 inhibitor. Moreover, IL-1β production was inhibited by a phagocytosis inhibitor.
ISSN:1344-6606
1881-3984
DOI:10.3136/fstr.18.481