Preoperative BRAF inhibition in patients with irresectable locally advanced stage III melanoma

Neoadjuvant treatment of locally advanced disease with inhibitors is expected to increase the likelihood of a R0 resection. We present six patients with stage III unresectable melanoma, neoadjuvantly treated with inhibitors. Patients with unresectable, -mutated, stage III melanoma, were treated with...

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Bibliographic Details
Published inMelanoma management Vol. 5; no. 2; p. MMT08
Main Authors Faut, Marloes, Jalving, Mathilde, Diercks, Gilles F, Hospers, Geke A, van Leeuwen, Barbara L, Been, Lukas B
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.06.2018
Taylor & Francis Group
Subjects
BRAF inhibitor
Case Series
Clinical trials
Immunotherapy
Medical imaging
Melanoma
Metastasis
Mutation
neoadjuvant
Outpatient care facilities
surgical resection
unresectable
Netherlands
BRAF inhibitor
melanoma
neoadjuvant
surgical resection
unresectable
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Summary:Neoadjuvant treatment of locally advanced disease with inhibitors is expected to increase the likelihood of a R0 resection. We present six patients with stage III unresectable melanoma, neoadjuvantly treated with inhibitors. Patients with unresectable, -mutated, stage III melanoma, were treated with inhibitors between 2012 and 2015. Unresectability was determined based on clinical and/or radiological findings. At maximal response, resection was performed. The specimen was reviewed to determine the degree of response. In five of six patients a radical resection was achieved. Postoperative complications were unremarkable. In five of six resected specimens, vital tumor tissue was found. Neoadjuvant inhibitor treatment of locally advanced melanoma is feasible and has the potential to facilitate an R0 resection.
ISSN:2045-0885
2045-0893
DOI:10.2217/mmt-2018-0002