Risk of post-operative bleeding after dentoalveolar surgery in patients taking anticoagulants: a cohort study using the common data model

• Published in: Scientific reports Vol. 14; no. 1; p. 7787
• Main Authors: Lee, Joo-Yeon, Park, Seung-Hyun, Kim, Da-Mi, Ko, Kyung-A, Park, Jin-Young, Lee, Jung-Seok, Jung, Ui-Won, Cha, Jae-Kook
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 02.04.2024; Nature Publishing Group UK; Nature Portfolio
• Subjects: Administration, Oral; Anticoagulants; Anticoagulants - adverse effects; Atrial Fibrillation - complications; Bleeding; Bone grafts; Bone surgery; Cohort Studies; Grafting; Humans; Maintenance; Patients; Postoperative Hemorrhage - chemically induced; Postoperative Hemorrhage - etiology; Retrospective Studies; Risk factors; Skin & tissue grafts; Statistical analysis; Statistical methods; Surgery; Surgical operations; Teeth; Tooth Extraction - adverse effects; Vitamin K
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-57881-7

This retrospective study aimed to determine risk factors associated with post-operative bleeding after dentoalveolar surgery in patients taking anticoagulants. Patients taking anticoagulants who were planned to undergo periodontal flap operation, tooth extraction or implant surgery were included. Patients were divided into two subgroups according to the maintenance of anticoagulants following medical consultation: (1) maintenance group and (2) discontinuation group. The analysed patient-related factors included systemic diseases, maintenance of anticoagulants and types of anticoagulant. Intra- and post-operative treatment-related factors, haemostatic methods and post-operative bleeding were collected for statistical analyses. There were 35 post-operative bleeding complications (6.5%) in the 537 included patients: 21 (8.6%) in maintenance group and 14 (4.8%) in discontinuation group. The type of anticoagulant (p = 0.037), tooth extraction combined with bone grafting (p = 0.016) and type of implant surgery (p = 0.032) were significantly related to the post-operative bleeding rate. In the maintenance group, atrial fibrillation [odds ratio (OR) = 6.051] and vitamin K inhibitors (OR = 3.679) were associated with a significantly higher bleeding risk. From this result, it can be inferred that the decision to continue anticoagulants should be made carefully based on the types of anticoagulant and the characteristics of dentoalveolar surgeries performed: extraction with bone grafting, multiple implantations and involvement of maxillary arch.