The DECON pilot project investigates predictive markers for successful bariatric surgery

• Published in: Scientific reports Vol. 13; no. 1; p. 13401
• Main Authors: Seifert, Gabriel, Fagnocchi, Luca, Edozie, Michael, Herrmann, Stephan, Baumann, Hannah, Panzeri, Ilaria, Mewes, Stephanie, Aicher, David, Runkel, Mira, Lässle, Claudia, Fink, Jodok, Marjanovic, Goran, Fichtner-Feigl, Stephan, Pospisilik, J Andrew
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 17.08.2023; Nature Publishing Group UK; Nature Portfolio
• Subjects: Bariatric Surgery; Body weight; Body weight loss; Gastrointestinal surgery; Heterogeneity; Humans; Obesity; Obesity - surgery; Obesity, Morbid - surgery; Patients; Pilot Projects; Surgery; Weight control; Weight Loss
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-40452-7

Obesity is a chronic, multifactorial disease which is linked to a number of adverse endocrinological and metabolic conditions. Currently, bariatric surgery is one of the most effective treatments for individuals diagnosed with severe obesity. However, the current indications for bariatric surgery are based on inadequate metrics (i.e., BMI) which do not account for the complexity of the disease, nor the heterogeneity among the patient population. Moreover, there is a lack of understanding with respect to the biological underpinnings that influence successful and sustained weight loss post-bariatric surgery. Studies have implicated age and pre-surgery body weight as two factors that are associated with favorable patient outcomes. Still, there is an urgent medical need to identify other potential factors that could improve the specificity of candidate selection and better inform the treatment plan of patients with obesity. In this report, we present and describe the cohort of the DECON pilot project, a multicenter study which aims to identify predictive biomarkers of successful weight loss after bariatric surgery.