Population-based retrospective cohort study on community-acquired pneumonia hospitalization in children with a ventricular septal defect

• Published in: Scientific reports Vol. 14; no. 1; p. 9307
• Main Authors: Sung, Myongsoon, Kim, Ju Hee, Ha, Eun Gyo, Shin, Jeewon, Kwak, Ji Hee, Jee, Hye Mi, Han, Man Yong
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 23.04.2024; Nature Publishing Group UK; Nature Portfolio
• Subjects: Adolescent; Aortic stenosis; Asthma; Asthma - complications; Asthma - epidemiology; Bioethics; Birth defects; Child; Child, Preschool; Children; Children & youth; Cohort analysis; Cohorts; Community-Acquired Infections - epidemiology; Congenital diseases; Coronary vessels; Female; Health services utilization; Heart failure; Heart Septal Defects, Ventricular - complications; Heart Septal Defects, Ventricular - epidemiology; Hospitalization; Hospitals; Humans; Incidence; Infant; Male; Medical screening; National health insurance; Pediatrics; Pneumonia; Pneumonia - epidemiology; Population; Population studies; Proportional Hazards Models; Pulmonary arteries; Respiratory system; Retrospective Studies; Review boards; Risk Factors; Veins & arteries; Ventricle
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-59510-9

The cohort consisted of 9400 exposed children diagnosed with ventricular septal defect (VSD). The risk of community-acquired pneumonia (CAP) or asthma with VSD was assessed using the Cox proportional hazard model with an inverse probability of treatment weighting. During a mean follow-up of 6.67 years (starting from 12 months after birth), there were 2100 CAP admission cases among exposed patients (incidence rate: 33.2 per 1000 person-years) and 20,109 CAP admission cases among unexposed children (incidence rate: 29.6 per 1000 person-years), with hazard ration of 1.09 (95% CI 1.04-1.14).