The relationship of atrial fibrillation with left atrial size in patients with essential hypertension

• Published in: Scientific reports Vol. 14; no. 1; p. 1250
• Main Authors: Saadeh, Rami, Abu Jaber, Bara, Alzuqaili, Taqwa, Ghura, Sara, Al-Ajlouny, Taiba, Saadeh, Abdallah M
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 13.01.2024; Nature Publishing Group UK; Nature Portfolio
• Subjects: Age; Aged; Apnea; Arrhythmia; Atrial Fibrillation; Cardiac arrhythmia; Cardiovascular disease; Cardiovascular diseases; Congestive heart failure; Coronary artery disease; Coronary Artery Disease - complications; Coronary vessels; Diabetes mellitus; Essential Hypertension - complications; Female; Fibrillation; Heart diseases; Heart failure; Heart Failure - complications; Humans; Hypertension; Hypertension - complications; Hypertension - epidemiology; Hypertrophy; Male; Mathematical models; Middle Aged; Public health; Retrospective Studies; Risk Factors; Sleep disorders; Statistical analysis; Stroke Volume; Vein & artery diseases; Ventricle; Ventricular Function, Left
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-51875-1

Atrial fibrillation (AF) is the most common sustained arrhythmia and it is a major public health problem worldwide. Hypertension is one of the major risk factors for the development of AF. This study is carried out to determine the prevalence and independent risk factors for atrial fibrillation (AF) in hypertensive patients and to evaluate the relationship of AF with left atrial size. This is a retrospective observational cross - sectional study that used a retrospective electronic chart review of all admitted patients to cardiology department at King Abdullah university hospital (KAUH) in Irbid, Jordan, with a diagnosis of hypertension along with various acute cardiac admissions, including AF during 1-year period (January 1st to December 31 of 2021). Risk factors for AF (age, sex, DM, coronary artery disease, valvular heart disease, Cor-pulmonale, obstructive sleep apnea, and congestive cardiac failure) were retrieved from electronic charts of the patients. A total of 958 patients were admitted to the coronary care unit (CCU) and intermediate care unit (IMCU) during a 1-year period. Among them, 276 had 2 or 3 admissions. The main reason of admission was acute coronary syndrome (n = 491), heart failure (n = 180), and AF (n = 144), indicating AF prevalence of 15%. However, there were 40 patients with combined causes. All patients in the study (n = 958) were diagnosed with hypertension, including patients with atrial fibrillation (n = 144). The mean age of patients was 61.4 (± 11.46) years, and approximately two thirds of them were males (65.4%). The binary logistic regression model demonstrated a significant statistical relationship of age, left atrial size, coronary artery disease, left ventricular ejection fraction, left ventricular dimensions in systole and diastole, and heart failure with the occurrence of AF after controlling for gender, smoking, and diabetes. Findings indicate that left atrial size plays a significant role in the development of AF in patients with hypertension. However, the prevalence of AF significantly increased with advancing age in both sexes because of increased left ventricular hypertrophy, which leads to increased left atrial size.