Multiple step saccades are generated by internal real-time saccadic error correction

• Published in: Frontiers in neuroscience Vol. 17; p. 1112655
• Main Authors: Ma, Wenbo, Zhang, Mingsha
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 28.02.2023; Frontiers Media S.A
• Subjects: anti-saccade; Error correction & detection; Eye movements; Hypotheses; internal model; Latency; Memory; memory-guided saccade; multiple step saccades; Neuroscience; Parkinson's disease; reactive saccades; Saccadic eye movements; internal model; multiple step saccades; reactive saccades; memory-guided saccade; anti-saccade
• ISSN: 1662-4548; 1662-453X; 1662-453X
• DOI: 10.3389/fnins.2023.1112655

Multiple step saccades (MSSs) are an atypical form of saccade that consists of a series of small-amplitude saccades. It has been argued that the mechanism for generating MSS is due to the automatic saccadic plan. This argument was based on the observation that trials with MSS had shorter saccadic latency than trials without MSS in the reactive saccades. However, the validity of this argument has never been verified by other saccadic tasks. Alternatively, we and other researchers have speculated that the function of MSS is the same as that of the corrective saccade (CS), i.e., to correct saccadic errors. Thus, we propose that the function of the MSS is also to rectify saccadic errors and generated by forward internal models. The objective of the present study is to examine whether the automatic theory is universally applicable for the generation of MSSs in various saccadic tasks and to seek other possible mechanisms, such as error correction by forward internal models. Fifty young healthy subjects (YHSs) and fifty elderly healthy subjects (EHSs) were recruited in the present study. The task paradigms were prosaccade (PS), anti-saccade (AS) and memory-guided saccade (MGS) tasks. Saccadic latency in trials with MSS was shorter than without MSS in the PS task but similar in the AS and MGS tasks. The intersaccadic intervals (ISI) were similar among the three tasks in both YHSs and EHSs. Our results indicate that the automatic theory is not a universal mechanism. Instead, the forward internal model for saccadic error correction might be an important mechanism.