Adolescent meningococcal serogroup A, W and Y immune responses following immunization with quadrivalent meningococcal A, C, W and Y conjugate vaccine: Optimal age for vaccination

• Published in: Vaccine Vol. 35; no. 36; pp. 4753 - 4760
• Main Authors: van Ravenhorst, Mariëtte B, van der Klis, Fiona R.M, van Rooijen, Debbie M, Sanders, Elisabeth A.M, Berbers, Guy A.M
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 24.08.2017; Elsevier Limited
• Subjects: Adolescent; Adolescents; Age; Age Factors; Allergy and Immunology; Animals; Antibodies, Bacterial - blood; Antibody; Child; Complement System Proteins; Conjugate vaccine; Disease; Europe - epidemiology; Female; Fluorescence; Humans; Immune response; Immunization; Immunization, Secondary; Immunoassay; Immunoglobulin G; Immunoglobulin G - blood; Immunoglobulins; Incidence; Male; Medical ethics; Meningococcal Infections - epidemiology; Meningococcal Infections - prevention & control; Meningococcal Vaccines - immunology; Multiplexing; Neisseria meningitidis; Neisseria meningitidis - immunology; Neisseria meningitidis, Serogroup Y - immunology; Netherlands - epidemiology; Population studies; Quadrivalent meningococcal vaccine; Rabbits; Research ethics; Serogroup; Serum Bactericidal Antibody Assay; Teenagers; Tetanus; Time Factors; Vaccination; Vaccination - methods; Vaccines; Netherlands; United Kingdom > UK; Europe; Africa; TT; geometric mean concentration; PS; invasive meningococcal disease; polysaccharide; MenW; Conjugate vaccine; MenY; 1 year after the study vaccination; meningococcal serogroup C conjugated vaccine; Medical research Ethics Committees United; Quadrivalent meningococcal vaccine; 1 month after the study vaccination; multiplex immunoassay; geometric mean titer; rSBA; UK; meningococcal serogroup C; GMC; meningococcal serogroup A; T0; T1; tetanus toxoid; T2; IMD; MIA; Antibody; CI; MenC; United Kingdom; before the study vaccination; Neisseria meningitidis; MEC-U; GMT; MenA; meningococcal serogroup Y; serum bactericidal assay using baby rabbit complement; meningococcal serogroup W; Adolescent; confidence interval; MenCC
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2017.06.007

Highlights • MenACWY-TT vaccine induces robust primary responses against meningococcal serogroups A, W and Y. • 94% of the participants maintain rSBA titers ≥128 against all three serogroups up to one year. • Compared with 12 and 15 years the 10-year-olds show the lowest SBA titers against MenW after one year.