Mechanical behavior of full-thickness burn human skin is rate-independent

• Published in: Scientific reports Vol. 14; no. 1; p. 11096
• Main Authors: Gallagher, Samara, Josyula, Kartik, Rahul, Kruger, Uwe, Gong, Alex, Song, Agnes, Eschelbach, Emily, Crawford, David, Pham, Tam, Sweet, Robert, Parsey, Conner, Norfleet, Jack, De, Suvranu
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 15.05.2024; Nature Publishing Group UK; Nature Portfolio
• Subjects: Adult; Biomechanical Phenomena; Burns; Classification; Elasticity; Female; Humans; Hypothesis testing; Male; Mechanical properties; Middle Aged; Skin; Skin Physiological Phenomena; Strain; Stress, Mechanical; Tensile Strength; Tensile stress; Toughness
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-61556-8

Skin tissue is recognized to exhibit rate-dependent mechanical behavior under various loading conditions. Here, we report that the full-thickness burn human skin exhibits rate-independent behavior under uniaxial tensile loading conditions. Mechanical properties, namely, ultimate tensile stress, ultimate tensile strain, and toughness, and parameters of Veronda-Westmann hyperelastic material law were assessed via uniaxial tensile tests. Univariate hypothesis testing yielded no significant difference (p > 0.01) in the distributions of these properties for skin samples loaded at three different rates of 0.3 mm/s, 2 mm/s, and 8 mm/s. Multivariate multiclass classification, employing a logistic regression model, failed to effectively discriminate samples loaded at the aforementioned rates, with a classification accuracy of only 40%. The median values for ultimate tensile stress, ultimate tensile strain, and toughness are computed as 1.73 MPa, 1.69, and 1.38 MPa, respectively. The findings of this study hold considerable significance for the refinement of burn care training protocols and treatment planning, shedding new light on the unique, rate-independent behavior of burn skin.