Associations of VCAM-1 gene polymorphisms with obesity and inflammation markers

• Published in: Inflammation research Vol. 66; no. 3; pp. 217 - 225
• Main Authors: Yu, Gyeong Im, Jun, Sang Eun, Shin, Dong Hoon
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2017; Springer Nature B.V
• Subjects: Adult; Allergology; Asian Continental Ancestry Group - genetics; Biomedical and Life Sciences; Biomedicine; C-Reactive Protein - analysis; Dermatology; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Immunology; Inflammation - blood; Inflammation - genetics; Intercellular Adhesion Molecule-1 - genetics; Leukocyte Count; Male; Middle Aged; Neurology; Obesity - blood; Obesity - genetics; Original Research Paper; Pharmacology/Toxicology; Polymorphism, Single Nucleotide; Rheumatology; Uric Acid - blood; Vascular Cell Adhesion Molecule-1 - genetics; Obesity; VCAM-1; ICAM-1; Inflammation
• ISSN: 1023-3830; 1420-908X; 1420-908X
• DOI: 10.1007/s00011-016-1006-2

Objective Among the inflammatory mediators involved in the pathogenesis of obesity, cell adhesion molecules such as intercellular adhesion molecule-1 ( ICAM - 1 ) and vascular adhesion molecule-1 ( VCAM - 1 ) stand out. The aim of this study was to investigate the associations of ICAM - 1 and VCAM - 1 gene variants with obesity and to investigate the associations between these genetic polymorphisms and CRP, UA, and WBC count. Method Four SNPs of the VCAM - 1 gene (rs3176860, rs2392221, rs3917010 and rs3176879) and two SNPs of the ICAM - 1 gene (rs281432 and rs5498) were analyzed in 181 control (18 < BMI < 23) and 144 obese (BMI ≥ 25) subjects. The SNPs were genotyped by direct sequencing. Results In allele frequency analysis, the G allelic frequency of rs3176860 in the VCAM - 1 gene was lower in the obese group (30.9%) than in the controls (41.2%) ( P  = 0.007). The C allelic frequency of rs3917010 was lower in the obese group (18.1%) than in the control (25.1%) ( P  = 0.03). In the haplotype analysis of VCAM - 1 gene, the ht1 (ACA) was higher and ht2 (GCC) was lower in the obese subjects than in the controls ( P  = 0.0057 and P  = 0.037, respectively). In the obese group, participants carrying the G allele of rs3176860 of the VCAM - 1 gene showed a higher percentage of segmented neutrophils and CRP levels than those carrying only the A allele ( P  = 0.028 and P  = 0.042, respectively). Conclusions The results of this study suggest that VCAM - 1 gene variants may be related to obesity and inflammatory markers in the Korean population.