Effects of small-fiber neuropathy induced by resiniferatoxin on skin healing and axonal regrowth after burn

• Published in: Burns Vol. 43; no. 3; pp. 562 - 572
• Main Authors: Laverdet, Betty, Girard, Dorothée, Bayout, Audrey, Bordeau, Nelly, Demiot, Claire, Desmoulière, Alexis
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.05.2017; Elsevier
• Subjects: Animals; axonal regrowth; Burn; Burns - complications; Burns - physiopathology; Chemical Sciences; Critical Care; Diterpenes - toxicity; Engineering Sciences; Ganglia, Spinal - pathology; Ganglia, Spinal - physiopathology; Granulation Tissue - physiopathology; Immunoblotting; Immunohistochemistry; Life Sciences; Male; Material chemistry; Materials; Microscopy, Electron, Transmission; Nerve Regeneration - physiology; Neuronal Outgrowth - physiology; Nociception; Peripheral neuropathy; Rats; Rats, Sprague-Dawley; Resiniferatoxin; Sciatic Nerve - physiopathology; Sciatic Nerve - ultrastructure; Skin healing; Small Fiber Neuropathy - chemically induced; Small Fiber Neuropathy - complications; Small Fiber Neuropathy - physiopathology; Small nerve fiber; Wound Healing - physiology; resiniferatoxin; α-smooth muscle actin; growth associated protein 43; Small nerve fiber; PGP 9.5; protein gene product 9.5; calcitonin gene-related peptide; TRPV1; Peripheral neuropathy; Burn; Skin healing; axonal regrowth; α-SMA; GAP43; dorsal root ganglion; RTX; DRG; transient receptor potential vanilloid-1; CGRP; Resiniferatoxin; Axonal regrowth
• ISSN: 0305-4179; 1879-1409
• DOI: 10.1016/j.burns.2016.09.016

Highlights • Resiniferatoxin promoted transient hypoalgesia without inducing nerve degeneration. • Neuropeptides were depleted in cell bodies and endings of primary sensory neurons. • Resiniferatoxin-mediated neuropathy delayed granulation tissue remodeling after burn. • The proportion of small fibers expressing peripherin was reduced during healing. • After burn healing, nerve regrowth and plasticity within the wound were not modified.