P53 and Ki-67 expression in primary pediatric brain tumors: Does it correlate with presentation, histological grade, and outcome?

• Published in: Asian journal of neurosurgery Vol. 13; no. 4; pp. 1026 - 1032
• Main Authors: Sharma, Vikas, Shoaib, Yawar, Gupta, Laxmi, Dagar, Amit
• Format: Journal Article
• Language: English
• Published: A-12, 2nd Floor, Sector 2, Noida-201301 UP, India Thieme Medical and Scientific Publishers Pvt. Ltd 01.10.2018; Wolters Kluwer India Pvt. Ltd; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd
• Subjects: Brain tumors; Development and progression; Ki-67 antigen; Original; Original Article; Patient outcomes; Pediatric tumors; Physiological aspects; Prognosis; Tumor proteins; Ki-67; WHO grade; pediatric brain tumors; p53
• ISSN: 1793-5482; 2248-9614
• DOI: 10.4103/ajns.AJNS_69_17

Context: Pediatric brain tumors are a vexing problem for the neurosurgeon due to the fragile patient cohort. We attempt to find parameters which can help us to treat and prognosticate these patients in a better way. Aims: This study aims to correlate clinical presentation, outcome, and histological grade with P53 and Ki-67 expression in primary pediatric brain tumors. Setting Design: This was a prospective, observational study. Patients and Methods: Forty-seven patients with primary brain tumors in the age group 0–18 years were included in this study. Clinical presentation was noted. Patients were operated, and specimen was sent for histopathological and immunohistochemistry examination for p53 and Ki-67. The WHO classification of 2007 was used to grade the tumors. Follow-up was done at 3 and 6 months with Glasgow outcome score. Expression of p53 and Ki-67 in different tumors was correlated with clinical presentation, tumor grade and outcome. Analysis Method: Statistical Package for Social Science version 17. P < 0.05 was considered statistically significant. Results: There was statistically significant correlation between high tumor grade and high Ki-67 levels (P = 0.000). On post hoc analysis, there was a significant difference between p53 levels in Grade 1 and Grade 4 tumors. There was statistically significant correlation between neurological deficit and higher p53 levels (P = 0.040). There was statistically significant correlation between poor outcome and higher p53 (P = 0.034) and Ki-67 (P = 0.000) levels at 3 months follow-up which continued at 6 months. Conclusions: From this study, we conclude that p53 and Ki-67 expression in pediatric brain tumors is associated with poor outcome and correlates with tumor grade. Moreover, p53 expression correlates with neurological deficit.