Multinuclear Catalyst for Copper-Catalyzed Asymmetric Conjugate Addition of Organozinc Reagents

A whole lot o' metal: An efficient copper‐catalyzed asymmetric conjugate addition was achieved using a binol‐derived ligand. The catalytic system has a turnover number of 2000, and the excellent catalytic performance could be attributed to the generation of a multinuclear complex such as 1. bin...

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Published inAngewandte Chemie International Edition Vol. 49; no. 13; pp. 2410 - 2413
Main Authors Endo, Kohei, Ogawa, Mika, Shibata, Takanori
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 22.03.2010
WILEY‐VCH Verlag
Wiley
Subjects
alkylation
Catalysis
Chemistry
Chemistry, Multidisciplinary
copper
Copper - chemistry
Michael addition
Molecular Structure
Organometallic Compounds - chemistry
Physical Sciences
Science & Technology
synthetic methods
zinc
Zinc - chemistry
Michael addition
MICHAEL REACTION
ET2ZN/LINKED-BINOL COMPLEX
QUATERNARY CENTERS
BETA-AMINO ALCOHOLS
ACYCLIC ENONES
MANNICH-TYPE REACTION
ALDOL REACTION
ENANTIOSELECTIVE HYDROGENATION
LINKED-BINOL
alkylation
copper
zinc
synthetic methods
GRIGNARD-REAGENTS
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Summary:A whole lot o' metal: An efficient copper‐catalyzed asymmetric conjugate addition was achieved using a binol‐derived ligand. The catalytic system has a turnover number of 2000, and the excellent catalytic performance could be attributed to the generation of a multinuclear complex such as 1. binol=2,2′‐dihydroxy‐1,1′‐binaphthyl.
Bibliography:Waseda University Grant for Special Research Projects
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ArticleID:ANIE200906839
K.E. is the recipient of the Teijin Pharma Award in Synthetic Organic Chemical Society (Japan). This work was supported financially by a Grant-in-Aid for Young Scientists (B) (No. 21750108) from the Japan Society for the Promotion of Science and by a Waseda University Grant for Special Research Projects.
Japan Society for the Promotion of Science
K.E. is the recipient of the Teijin Pharma Award in Synthetic Organic Chemical Society (Japan). This work was supported financially by a Grant‐in‐Aid for Young Scientists (B) (No. 21750108) from the Japan Society for the Promotion of Science and by a Waseda University Grant for Special Research Projects.
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200906839