THE COMPLETE ASSIGNMENT OF THE 13C NMR SPECTRA OF LASALOCID AND THE SODIUM SALT-COMPLEX OF THE ANTIBIOTIC

All thirty-four signals observed in the 13C nmr of both the free acid form (Ia) and sodium salt (Ib) of the polyether antibiotic lasalocid have been assigned. This was achieved using model compounds such as 3-methylsalicylic acid, the retroaldol ketones from both lasalocid and lysocellin and a γ-lac...

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Bibliographic Details
Published inJournal of antibiotics Vol. 31; no. 4; pp. 289 - 293
Main Authors SETO, HARUO, WESTLEY, JOHN W., PITCHER, ROSS G.
Format Journal Article
LanguageEnglish
Published Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1978
Subjects
Anti-Bacterial Agents - analysis
Chemical Phenomena
Chemistry
Crystallization
Lasalocid - analysis
Magnetic Resonance Spectroscopy
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Summary:All thirty-four signals observed in the 13C nmr of both the free acid form (Ia) and sodium salt (Ib) of the polyether antibiotic lasalocid have been assigned. This was achieved using model compounds such as 3-methylsalicylic acid, the retroaldol ketones from both lasalocid and lysocellin and a γ-lactone from a third polyether, salinomycin. The last assignments to be made were accomplished using biosynthetically enriched samples of the antibiotic.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.31.289