Apoptotic-related protein changes induced by hexavalent chromium in mice liver

• Published in: Environmental toxicology Vol. 25; no. 1; pp. 77 - 82
• Main Authors: Wang, Xiao-Feng, Lou, Xiao-Ming, Shen, Ying, Xing, Ming-Luan, Xu, Li-Hong
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2010; Wiley
• Subjects: Animal, plant and microbial ecology; Animals; apoptosis; Apoptosis - drug effects; Apoptosis - physiology; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; Applied ecology; Bax; Bcl-2; Biological and medical sciences; caspase-3; Cr(VI); cytochrome c; DNA Damage; Ecotoxicology, biological effects of pollution; Fundamental and applied biological sciences. Psychology; Gene Expression Profiling; Gene Expression Regulation - drug effects; General aspects; in vivo; Lethal Dose 50; Liver - drug effects; Liver - metabolism; Male; Mice; p53; Potassium Dichromate - toxicity; Cytochrome; Hexavalent metal; Bcl-2; Ecotoxicology; Toxicity; Liver; Rodentia; Protein; Heavy metal; p53; In vivo; Pollutant; Vertebrata; Mammalia; Cr(VI); Mouse; Chromium; Bax; Environment; cytochrome c; Apoptosis; caspase-3
• ISSN: 1520-4081; 1522-7278
• DOI: 10.1002/tox.20478

Although it has been reported that hexavalent chromium (Cr(VI)) could induce apoptosis in a variety of cell types, the molecular mechanisms underlying this process is still largely unknown. This study was undertaken to determine effects of single oral 0, 25, 50, and 100 mg/kg body weight doses of potassium dichromate on the expression level of p53, Bcl-2, Bax, cytochrome c, and caspase-3, which are vital regulators of apoptosis, in mice liver. The results showed that Cr(VI) could upregulate the protein expression of p53, Bax, cytochrome c, and caspase-3 and downregulate the expression of Bcl-2 in mice liver. All these results suggested that p53, Bcl-2, Bax, cytochrome c, and caspase-3 may be involved in the regulation of Cr(VI) induced apoptosis in vivo.