Electrocyclization-Based Labeling Allows Efficient In Vivo Imaging of Cellular Trafficking

Labeling the living! New synthetic chemistry allows living cells to be labeled for 10 min at extremely low concentrations without deactivating cell functions; lymphocyte trafficking was visualized with high‐contrast fluorescence imaging at the whole‐body level.

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Bibliographic Details
Published inChemMedChem Vol. 5; no. 6; pp. 841 - 845
Main Authors Tanaka, Katsunori, Minami, Kaori, Tahara, Tsuyoshi, Fujii, Yohei, Siwu, Eric R. O., Nozaki, Satoshi, Onoe, Hirotaka, Yokoi, Satomi, Koyama, Koichi, Watanabe, Yasuyoshi, Fukase, Koichi
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 07.06.2010
WILEY‐VCH Verlag
Subjects
Animals
Cell Movement
Contrast Media - chemical synthesis
Contrast Media - chemistry
Cyclization
Electrochemical Techniques
electrocyclic reactions
Fluorescent Dyes - chemistry
fluorescent probes
imaging agents
lysine
Mice
Microscopy, Confocal
Positron-Emission Tomography
Rhodamines - chemistry
Whole Body Imaging
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Summary:Labeling the living! New synthetic chemistry allows living cells to be labeled for 10 min at extremely low concentrations without deactivating cell functions; lymphocyte trafficking was visualized with high‐contrast fluorescence imaging at the whole‐body level.
Bibliography:MEXT
ark:/67375/WNG-36C5STL7-8
ArticleID:CMDC201000027
Japan Science and Technology Agency (JST)
Japan Society for the Promotion of Science - No. 19681024; No. 19651095
Ministry of Education, Culture, Sports, Science and Technology
New Energy and Industrial Technology Development Organization - No. 07A01014a
istex:AE221585316E1EF603325CE1AC1B040311110B94
Yamada Science Foundation
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.201000027