Nanoscale-Controlled Enzymatic Degradation of Poly(L-lactic acid) Films Using Dip-Pen Nanolithography

Proteinase K is patterned on poly(L‐lactic acid) (PLLA) film by agarose‐assisted dip‐pen nanolithography. Lateral biodegradation at the nanometer scale on PLLA film is faster than vertical biodegradation. The height and diameter of the patterned proteinase K dots can affect the depth of the biodegra...

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Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 7; no. 2; pp. 226 - 229
Main Authors Li, Hai, He, Qiyuan, Wang, Xiaohong, Lu, Gang, Liusman, Cipto, Li, Bing, Boey, Freddy, Venkatraman, Subbu S., Zhang, Hua
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 17.01.2011
WILEY‐VCH Verlag
Subjects
biodegradation
biological activity
dip-pen nanolithography
Endopeptidase K - metabolism
enzymes
Lactic Acid - chemistry
Microscopy, Atomic Force
Nanotechnology
patterning
Polymers - chemistry
Polymers - metabolism
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Summary:Proteinase K is patterned on poly(L‐lactic acid) (PLLA) film by agarose‐assisted dip‐pen nanolithography. Lateral biodegradation at the nanometer scale on PLLA film is faster than vertical biodegradation. The height and diameter of the patterned proteinase K dots can affect the depth of the biodegraded holes, while the concentration of the proteinase K solution (the ink used to coat the AFM tip) does not affect the biodegradation.
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ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201001977