Polysaccharides from Dicliptera chinensis ameliorate liver disturbance by regulating TLR‐4/NF‐κB and AMPK/Nrf2 signalling pathways

• Published in: Journal of cellular and molecular medicine Vol. 24; no. 11; pp. 6397 - 6409
• Main Authors: Zhang, Kefeng, Xu, Qiongmei, Gao, Ya, Cao, Houkang, Lian, Yuanyu, Li, Zimeng, Xu, Jie, Zhong, Mingli, Li, Jiani, Wei, Riming, Dong, Jianghui, Jin, Ling
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.06.2020; John Wiley and Sons Inc
• Subjects: Acanthaceae - chemistry; Adenosine kinase; AMP; AMP-Activated Protein Kinases - metabolism; AMPK/ Nrf2; Analgesics; Animals; Calories; Dicliptera chinensis; Dicliptera chinensis polysaccharides; Ethanol; Glucose metabolism; Hep G2 Cells; Humans; Inflammation; Laboratory animals; Lipid metabolism; Lipid Metabolism - drug effects; Liver; Liver - drug effects; Liver - metabolism; Liver - pathology; Liver - physiopathology; Liver diseases; liver disturbances; Male; Mice, Inbred C57BL; Models, Biological; NF-E2-Related Factor 2 - metabolism; NF-kappa B - metabolism; Original; Oxidative metabolism; Oxidative stress; Oxidative Stress - drug effects; Peroxisome proliferator-activated receptors; Polysaccharides; Polysaccharides - pharmacology; Protein expression; Protein kinase; Proteins; Signal transduction; Signal Transduction - drug effects; siRNA; Sterol regulatory element-binding protein; TLR‐4/ NF‐κB; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Tumor necrosis factor; Tumors; Beijing China; China; AMPK/ Nrf2; Dicliptera chinensis polysaccharides; TLR-4/ NF-κB; liver disturbances

The purpose of this study was to alleviate liver disturbance by applying polysaccharides from Dicliptera chinensis (DCP) to act on the adenosine monophosphate–activated protein kinase/ nuclear factor erythroid 2‐related factor 2 (AMPK/ Nrf2) oxidative stress pathway and the Toll‐like receptor 4 (TLR...