A High-Performance Ytterbium-Based Nanoparticulate Contrast Agent for In Vivo X-Ray Computed Tomography Imaging

Enlightening particles: A contrast agent for in vivo X‐ray computed tomography (CT) imaging is composed of an Yb‐based nanoparticle (NP) that is stabilized with oleic acid and modified with the biocompatible polymer DSPE‐PEG 2000 (see picture). The contrast agent exhibits long circulation time in vi...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 51; no. 6; pp. 1437 - 1442
Main Authors Liu, Yanlan, Ai, Kelong, Liu, Jianhua, Yuan, Qinghai, He, Yangyang, Lu, Lehui
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 06.02.2012
WILEY‐VCH Verlag
Subjects
Animals
Contrast Media - chemistry
HeLa Cells
Humans
imaging agents
magnetic resonance imaging
Metal Nanoparticles - chemistry
nanoparticles
Rats
Tomography, X-Ray Computed - methods
X-ray computed tomography
ytterbium
Ytterbium - chemistry
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Summary:Enlightening particles: A contrast agent for in vivo X‐ray computed tomography (CT) imaging is composed of an Yb‐based nanoparticle (NP) that is stabilized with oleic acid and modified with the biocompatible polymer DSPE‐PEG 2000 (see picture). The contrast agent exhibits long circulation time in vivo and low toxicity and is also much more effective than a clinical iodinated agent.
Bibliography:istex:BC8DC741D6DBC4A8A6699F8541F48DEC8FCA4C1F
Financial support by NSFC (Nos. 21125521, 21075117), the National Basic Research Program of China (973 Program, No. 2010CB933600), and the "Hundred Talents Project" of the Chinese Academy of Science is gratefully acknowledged.
ArticleID:ANIE201106686
NSFC - No. 21075117; No. 2010CB933600
ark:/67375/WNG-HTLJ6KZJ-X
Financial support by NSFC (Nos. 21125521, 21075117), the National Basic Research Program of China (973 Program, No. 2010CB933600), and the “Hundred Talents Project” of the Chinese Academy of Science is gratefully acknowledged.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201106686