Gastrointestinal factors associated with risk of bronchiectasis in children

• Published in: Pediatric pulmonology Vol. 58; no. 3; pp. 899 - 907
• Main Authors: Duncan, Daniel R., Cohen, Alexandra, Golden, Clare, Lurie, Margot, Mitchell, Paul D., Liu, Enju, Simoneau, Tregony, Rosen, Rachel L.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2023
• Subjects: Bronchiectasis - complications; Bronchiectasis - diagnostic imaging; Bronchiectasis - epidemiology; Child; Gastroesophageal reflux; Gastroesophageal Reflux - complications; Gastroesophageal Reflux - diagnosis; Gastroesophageal Reflux - epidemiology; gastrostomy tube; Humans; Lung; motility; Neutrophils; oropharyngeal dysphagia; Retrospective Studies; Risk Factors; motility; oropharyngeal dysphagia; gastrostomy tube; gastroesophageal reflux
• ISSN: 8755-6863; 1099-0496; 1099-0496
• DOI: 10.1002/ppul.26276

Objective To evaluate gastrointestinal (GI) risk factors for bronchiectasis in children. We hypothesized that upper GI tract dysmotility would be associated with increased risk of bronchiectasis. Study design Subjects in this retrospective cohort study included those evaluated for persistent pulmonary symptoms in the Aerodigestive Center at Boston Children's Hospital who underwent chest computed tomography (CT) between 2002 and 2019. To determine gastrointestinal predictors of bronchiectasis, baseline characteristics, comorbidities, enteral tube status, medications received, gastroesophageal reflux burden, adequacy of swallow function, esophageal dysmotility, gastric dysmotility, and neutrophil count on bronchoalveolar lavage (BAL) were compared between patients with and without bronchiectasis. Proportions were compared with Fisher's exact test and binary logistic regression with stepwise selection was used for multivariate analysis. ROC analyses were utilized to compare BAL neutrophils and bronchiectasis. Results Of 192 subjects, 24% were found to have evidence of bronchiectasis on chest CT at age 7.9 ± 0.5 years. Enteral tubes (OR 5.77, 95% CI 2.25–14.83, p < 0.001) and increased BAL neutrophil count (OR 5.79, 95% CI 1.87–17.94, p = 0.002) were associated with increased risk while neurologic comorbidities were associated with decreased risk (OR 0.24, 95% CI 0.09–0.66, p = 0.006). Gastroesophageal reflux was not found to be a significant risk factor. Neutrophil counts >10% had 72% sensitivity and 60% specificity for identifying bronchiectasis. Conclusions Enteral tubes were associated with significantly increased risk of bronchiectasis but gastroesophageal reflux was not. Providers should consider obtaining chest CT to evaluate for bronchiectasis in children found to have unexplained elevated BAL neutrophil count.