Recurrent hepatitis C after liver transplantation
Cirrhosis due to hepatitis C is now the commonest indication for liver transplantation in Western Europe and in the United States. Graft reinfection is almost universal. The natural history of recurrent hepatitis C ranges from minimal damage to cirrhosis in a few months or years. Different virus and...
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Published in | Journal of medical virology Vol. 61; no. 4; pp. 443 - 454 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
New York
John Wiley & Sons, Inc
01.08.2000
Wiley-Liss |
Subjects | |
Online Access | Get full text |
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Summary: | Cirrhosis due to hepatitis C is now the commonest indication for liver transplantation in Western Europe and in the United States. Graft reinfection is almost universal. The natural history of recurrent hepatitis C ranges from minimal damage to cirrhosis in a few months or years. Different virus and host immune factors are involved in the pathogenesis of hepatitis and are determinants of the outcome. The association between immunosuppression and severity of HCV recurrence is conflicting and remains to be evaluated fully. The treatment of recurrent HCV disease with IFN or ribavirin, as monotherapy, is ineffective. Preliminary results from combination therapy, however, are encouraging. Currently, a reasonable approach would be to treat patients with histological and clinical disease progression. New approaches for the prophylaxis of recurrent hepatitis C are under evaluation but whether this treatment will influence the severity of liver disease or the outcome of recurrence is still unknown. J. Med. Virol. 61:443–454, 2000. © 2000 Wiley‐Liss, Inc. |
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Bibliography: | ark:/67375/WNG-14FVXQKR-H ArticleID:JMV6 istex:365C73824F0F3D79CD3B527F598A5386488F3DDB ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1 |
ISSN: | 0146-6615 1096-9071 |
DOI: | 10.1002/1096-9071(200008)61:4<443::AID-JMV6>3.0.CO;2-Z |