Preoperative monocyte‐to‐HDL‐cholesterol ratio predicts early recurrence after radiofrequency maze procedure of valvular atrial fibrillation

• Published in: Journal of clinical laboratory analysis Vol. 35; no. 2; pp. e23595 - n/a
• Main Authors: Adili, Ailiya, Wang, Yali, Zhu, Xiyu, Cao, Hailong, Fan, Fudong, Tang, Xinlong, Zhou, Qing, Wang, Dongjin
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.02.2021; John Wiley and Sons Inc
• Subjects: Ablation; Biomarkers; Blood; Body mass index; Cardiac arrhythmia; Cardiovascular disease; Cardioversion; Cholesterol; Coronary artery disease; early recurrence; Fibrillation; Heart diseases; Heart failure; High density lipoprotein; Hospitals; Laboratories; Monocytes; monocyte‐to‐high‐density lipoprotein ratio; Multivariate analysis; Oxidative stress; radiofrequency maze procedure; Risk factors; Statistical analysis; Surgery; Triglycerides; valvular atrial fibrillation; early recurrence; valvular atrial fibrillation; monocyte-to-high-density lipoprotein ratio; radiofrequency maze procedure
• ISSN: 0887-8013; 1098-2825
• DOI: 10.1002/jcla.23595

Background Monocyte‐to‐high‐density lipoprotein (M/H) ratio has emerged as a novel cardiovascular prognostic biomarker. We aimed to evaluate the prognostic values of M/H with early recurrence in persistent valvular atrial fibrillation (AF) patients after radiofrequency (RF) maze procedure. Methods We retrospectively analyzed 131 consecutive persistent AF patients with valvular heart diseases who were followed up 3 months after RF maze procedure. Their clinical data were recorded. Logistic regression analyses were performed for significant predictors. Receiver operating characteristic analysis was used for validation with corresponding area under the curve. Results 70 (53.4%) patients experienced early recurrence after procedure. Patients with early recurrence were older, have longer AF duration history, larger left atria diameter (LAD), higher plasma C‐reactive protein (CRP), lower triglycerides (TG), lower cholesterol (TC), increased monocyte counts, lower HDL cholesterol, and increased M/H ratio. In multivariate analysis, age (OR 1.1 95% CI 1.0‐1.1 P = .003), LAD (OR 2.1, 95%CI 1.2‐3.5, P = .006), TG (OR 0.35, 95% CI 0.15‐0.84, P = .019), M/H (OR 6.1, 95% CI 2.9‐13.0, P < .001) were significantly independent predictors of AF early recurrence. M/H ratio demonstrated a significant predictive value (AUC = 0.77, sensitivity 89.0%, specificity 54%). Further, there was a positive correlation of M/H ratio with CRP and white blood cell. Conclusion Preoperative M/H ratio was an independent risk factor of AF early recurrence following RF maze operation. M/H ratio should be considered in prediction of early recurrence for valvular AF patients. Main Line.