Association of hematocrit with blood pressure and hypertension

• Published in: Journal of clinical laboratory analysis Vol. 31; no. 6
• Main Authors: Emamian, Marzieh, Hasanian, Seyed Mahdi, Tayefi, Maryam, Bijari, Moniba, Movahedian far, Faeze, Shafiee, Mojtaba, Avan, Amir, Heidari‐Bakavoli, Alireza, Moohebati, Mohsen, Ebrahimi, Mahmoud, Darroudi, Sousan, Zamani, Parvin, Azarpazhooh, Mahmoud Reza, Nematy, Mohsen, Safarian, Mohammad, Ferns, Gordon A., Esmaeili, Habibollah, Parizadeh, Mohammad Reza, Ghayour‐Mobarhan, Majid
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.11.2017; John Wiley and Sons Inc
• Subjects: Adult; Arteriosclerosis; biochemical risk factors; Biomarkers - blood; Blood pressure; Blood Pressure - physiology; Body Mass Index; C-reactive protein; cardiovascular diseases; Cholesterol; Cholesterol - blood; Erythrocytes; Female; Hematocrit; hematological parameters; Hematology; Hemoglobin; High density lipoprotein; Humans; Hypertension; Hypertension - blood; Hypertension - epidemiology; Hypertension - physiopathology; Low density lipoprotein; Male; Middle Aged; Renal failure; Risk Factors; Uric acid; Uric Acid - blood; cardiovascular diseases; biochemical risk factors; hypertension; hematological parameters
• ISSN: 0887-8013; 1098-2825
• DOI: 10.1002/jcla.22124

Background Hypertension (HTN) is a risk factor for stroke, renal failure, and cardiovascular disease. The association between biochemical and hematological parameters with high blood pressure may provide a more precise approach to risk prediction conferred by HTN in these patients. Objective The aim of current study was to explore whether biochemical and hematological parameters are associated with HTN in a cohort study with a 7‐year follow‐up. Materials and Methods A total of 9808 individuals were enrolled and recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study, and biochemical and hematological factors were measured in all subjects. Univariate and multivariate logistic regression analysis were performed to determine the association of biochemical and hematological parameters with HTN. Results Several biochemical parameters including fasting plasma glucose (FBG), serum high‐sensitivity C‐reactive protein (hs‐CRP), triglyceride (TG), total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), and uric acid were increased in hypertensive participants. In contrast, serum high‐density lipoprotein cholesterol (HDL‐C) was lower in hypertensive individuals. Furthermore, we demonstrated that hematological parameters including white blood cell (WBC) count, red blood cell (RBC) count, hemoglobin (HGB), hematocrit (HCT), and mean corpuscular hemoglobin (MCH) were higher in the hypertensive group compared to the control group. But mean corpuscular volume (MCV), and red cell distribution width (RDW), were decreased in the hypertensive group. Furthermore, our results strongly suggested that among these parameters, hematocrit was the independent risk factor for hypertension in the population. Conclusion We demonstrated the association of altered biochemical and hematological factors with hypertension supporting the value of emerging markers for early prediction of high blood pressure in prone individuals.