A high-performance liquid chromatographic method for the determination of stobadin pharmacokinetics in serum

A high-performance liquid chromatographic method was developed to determine stobadin pharmacokinetics in dog and man. The relative bioavailability of stobadin dipalmitate compared with dihydrochloride was 46.4 per cent in dog. In man peak serum concentrations ranged from 12 to 289 ng ml-1 after a si...

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Bibliographic Details
Published inBiopharmaceutics & drug disposition Vol. 12; no. 1; p. 29
Main Authors Soltés, L, Kállay, Z, Bezek, S, Fedelesová, V
Format Journal Article
LanguageEnglish
Published England 01.01.1991
Subjects
Administration, Oral
Adult
Animals
Anti-Arrhythmia Agents - administration & dosage
Anti-Arrhythmia Agents - blood
Anti-Arrhythmia Agents - pharmacokinetics
Biological Availability
Carbolines - administration & dosage
Carbolines - blood
Carbolines - pharmacokinetics
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid - methods
Dogs
Female
Humans
Male
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Summary:A high-performance liquid chromatographic method was developed to determine stobadin pharmacokinetics in dog and man. The relative bioavailability of stobadin dipalmitate compared with dihydrochloride was 46.4 per cent in dog. In man peak serum concentrations ranged from 12 to 289 ng ml-1 after a single oral dose of stobadin dipalmitate (0.79 to 2.5 mgkg-1).
ISSN:0142-2782
DOI:10.1002/bdd.2510120104