A review of the history, properties, and use of the immunomodulatory compound lenalidomide
Lenalidomide (REVLIMID™), an immunomodulatory compound targeting both cancer cells and their microenvironment, has substantial activity in several difficult‐to‐manage hematological malignancies. In previously treated multiple myeloma, lenalidomide produces high‐quality responses combined with sustai...
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Published in | Annals of the New York Academy of Sciences Vol. 1222; no. 1; pp. 76 - 82 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Malden, USA
Blackwell Publishing Inc
01.03.2011
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Lenalidomide (REVLIMID™), an immunomodulatory compound targeting both cancer cells and their microenvironment, has substantial activity in several difficult‐to‐manage hematological malignancies. In previously treated multiple myeloma, lenalidomide produces high‐quality responses combined with sustained disease control. Recently, several randomized studies have demonstrated a clinical benefit of continuous lenalidomide treatment in newly diagnosed multiple myeloma. In many patients with refractory anemia associated with lower risk myelodysplastic syndromes and a 5q chromosome deletion, lenalidomide leads to transfusion independence, considerably improving quality of life. It has a manageable safety profile, and its oral formulation reduces the burden on patients. Several phase III trials are ongoing in other indications currently underserved by conventional therapy, such as chronic lymphocytic leukemia, non‐Hodgkin's lymphoma, and prostate cancer. Several early‐stage studies are exploring lenalidomide alone and in combination across different hematological malignancies, solid tumors, and immune‐related disorders. |
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Bibliography: | istex:CD6CDA20E8F55AE359C0A80A9A963D8DE4A5B20E ArticleID:NYAS5974 ark:/67375/WNG-F4RFLKTX-K ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0077-8923 1749-6632 |
DOI: | 10.1111/j.1749-6632.2011.05974.x |