Proteome and proteomics: new technologies, new concepts, and new words

The goal of proteomics is a comprehensive, quantitative description of protein expression and its changes under the influence of biological perturbations such as disease or drug treatment. Quantitative analysis of protein expression data obtained by high-throughput methods has led us to define the c...

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Bibliographic Details
Published inElectrophoresis Vol. 19; no. 11; p. 1853
Main Authors Anderson, N L, Anderson, N G
Format Journal Article
LanguageEnglish
Published Germany 01.08.1998
Subjects
Humans
Proteins - analysis
Proteins - drug effects
RNA, Messenger - analysis
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Summary:The goal of proteomics is a comprehensive, quantitative description of protein expression and its changes under the influence of biological perturbations such as disease or drug treatment. Quantitative analysis of protein expression data obtained by high-throughput methods has led us to define the concept of "regulatory homology" and use it to begin to elucidate the basic structure of gene expression control in vivo. Such investigations lay the groundwork for construction of comprehensive databases of mechanisms (cataloguing possible biological outcomes), the next logical step after the soon to be completed cataloguing of genes and gene products. Mechanism databases provide a roadmap towards effective therapeutic intervention that is more direct than that offered by conventional genomics approaches.
ISSN:0173-0835
DOI:10.1002/elps.1150191103