Is the first urinary albumin/creatinine ratio (ACR) in women with suspected preeclampsia a prognostic factor for maternal and neonatal adverse outcome? A retrospective cohort study

• Published in: Acta obstetricia et gynecologica Scandinavica Vol. 96; no. 5; pp. 580 - 588
• Main Authors: Elia, Eleni G., Robb, Amy O., Hemming, Karla, Price, Malcolm J., Riley, Richard D., French‐Constant, Anna, Denison, Fiona C., Kilby, Mark D., Morris, Rachel K., Stock, Sarah J.
• Format: Journal Article
• Language: English; French; German
• Published: United States John Wiley & Sons, Inc 01.05.2017; John Wiley and Sons Inc
• Subjects: ACR; Adult; adverse events; albumin to creatinine ratio; Albuminuria - diagnosis; Albuminuria - urine; Cohort Studies; cohort study; Creatinine - urine; Female; Health risk assessment; Humans; Infant, Newborn; Multivariate analysis; Original; Pre-Eclampsia - diagnosis; Pre-Eclampsia - urine; Predictive Value of Tests; Preeclampsia; Pregnancy; Pregnancy Outcome; Prenatal Diagnosis; Prognosis; Proteinuria - diagnosis; Proteinuria - urine; Retrospective Studies; risk factors; Scotland; Scotland; ACR; risk factors; cohort study; Preeclampsia; adverse events; albumin to creatinine ratio; prognosis
• ISSN: 0001-6349; 1600-0412
• DOI: 10.1111/aogs.13123

Introduction The aim of this study was to determine the prognostic value of the first urinary albumin/creatinine ratio (ACR) for adverse maternal and neonatal outcomes and how it relates to other prognostic factors. Material and methods We performed a retrospective cohort study from December 2009 to February 2012 with analysis of demographic, clinical and biochemical data from two obstetric day assessment units in hospitals in Southeast Scotland. We included 717 pregnant women, with singleton pregnancies after 20 weeks’ gestation, referred for evaluation of suspected preeclampsia and having their first ACR performed. The ability of ACR to predict future outcomes was assessed in both univariable and multivariable logistic regression models. The latter assessed its prognostic value independent of (adjusting for) existing prognostic factors. Primary outcome measures were maternal and neonatal composite adverse outcomes, and a secondary outcome was gestation at delivery. Results In all, 204 women (28.5%) experienced a composite adverse maternal outcome and 146 women (20.4%) experienced a composite adverse neonatal outcome. Multivariate analysis of log‐transformed ACR demonstrated that a 1‐unit increase in log ACR is associated with an increased odds of adverse maternal [odds ratio 1.60, 95% confidence interval (CI) 1.45–1.80] and adverse neonatal (odds ratio 1.15, 95% CI 1.02–1.29) composite outcomes, and with reduced gestational age at delivery (coefficient: −0.46, 95% CI −0.54 to −0.38). Conclusions ACR is an independent prognostic factor for maternal and neonatal adverse outcomes in suspected preeclampsia. ACR may be useful to inform risk predictions within a prognostic model.