Unbalanced distribution of materials: the art of giving rise to hepatocytes from liver stem/progenitor cells

Liver stem/progenitor cells (LSPCs) are able to duplicate themselves and differentiate into each type of cells in the liver, including mature hepatocytes and cholangiocytes. Understanding how to accurately control the hepatic differentiation of LSPCs is a challenge in many fields from preclinical to...

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Published inJournal of cellular and molecular medicine Vol. 18; no. 1; pp. 1 - 14
Main Authors Liu, Wei‐Hui, Ren, Li‐Na, Chen, Tao, You, Nan, Liu, Li‐Ye, Wang, Tao, Yan, Hong‐Tao, Luo, Hao, Tang, Li‐Jun
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.01.2014
Blackwell Publishing Ltd
Subjects
Animals
Antigens, Differentiation - metabolism
Cell cycle
Cell Differentiation
Cell Shape
Cytokines
hepatic differentiation, unbalanced distribution theory
Hepatocytes
Hepatocytes - physiology
Humans
Liver
Liver - cytology
Liver diseases
liver regeneration
liver stem/progenitor cells
Morphology
Phenotype
Progenitor cells
Regenerative Medicine
Reviews
Stem cells
Stem Cells - physiology
hepatic differentiation, unbalanced distribution theory
liver regeneration
hepatocytes
liver stem/progenitor cells
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Summary:Liver stem/progenitor cells (LSPCs) are able to duplicate themselves and differentiate into each type of cells in the liver, including mature hepatocytes and cholangiocytes. Understanding how to accurately control the hepatic differentiation of LSPCs is a challenge in many fields from preclinical to clinical treatments. This review summarizes the recent advances made to control the hepatic differentiation of LSPCs over the last few decades. The hepatic differentiation of LSPCs is a gradual process consisting of three main steps: initiation, progression and accomplishment. The unbalanced distribution of the affecting materials in each step results in the hepatic maturation of LSPCs. As the innovative and creative works for generating hepatocytes with full functions from LSPCs are gradually accumulated, LSPC therapies will soon be a new choice for treating liver diseases.
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These authors equally contributed to this work.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.12183