Multimodal Nanodiamond Drug Delivery Carriers for Selective Targeting, Imaging, and Enhanced Chemotherapeutic Efficacy

Multimodal nanodiamonds (NDs) were prepared by attaching fluorescently labeled drug‐oligonucleotide conjugates and monoclonal antibodies onto the ND surface. Fluorescently labeled oligonucleotide linkers enabled the intracellular observation and quantification of resultant ND conjugates. The covalen...

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Bibliographic Details
Published inAdvanced materials (Weinheim) Vol. 23; no. 41; pp. 4770 - 4775
Main Authors Zhang, Xue-Qing, Lam, Robert, Xu, Xiaoyang, Chow, Edward K., Kim, Ho-Joong, Ho, Dean
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 02.11.2011
WILEY‐VCH Verlag
Subjects
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Biological Transport
Cell Line, Tumor
DNA
Drug Carriers - chemistry
Drug Carriers - metabolism
drug delivery
Humans
Molecular Imaging - methods
Molecular Targeted Therapy - methods
nanodiamonds
Nanodiamonds - chemistry
nanomedicine
Paclitaxel
Paclitaxel - chemistry
Paclitaxel - pharmacology
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Summary:Multimodal nanodiamonds (NDs) were prepared by attaching fluorescently labeled drug‐oligonucleotide conjugates and monoclonal antibodies onto the ND surface. Fluorescently labeled oligonucleotide linkers enabled the intracellular observation and quantification of resultant ND conjugates. The covalent attachment of the chemotherapeutic and targeting moiety to the ND surface significantly enhanced cellular internalization and therapeutic activity
Bibliography:istex:B6CCEA30604796766C5804E07F78024B820B7293
ArticleID:ADMA201102263
ark:/67375/WNG-H8LKW928-8
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0935-9648
1521-4095
1521-4095
DOI:10.1002/adma.201102263