Sortase-Based Bio-organic Strategies for Macromolecular Synthesis

Protein ligation sorted: SrtA is one of the molecules nature uses to perform chemoselective ligation on amazingly complex protein molecules. Sortase‐mediated ligation (SML) with chemoselective reactions will find a variety of applications in chemistry, biology, and medicine in the near future.

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Bibliographic Details
Published inChembiochem : a European journal of chemical biology Vol. 15; no. 13; pp. 1857 - 1867
Main Authors Haridas, V., Sadanandan, Sandhya, Dheepthi, N. U.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 05.09.2014
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
Aminoacyltransferases - chemistry
Bacterial Proteins - chemistry
Carbohydrate Sequence
click chemistry
Cysteine Endopeptidases - chemistry
ligation
Macromolecular Substances - chemical synthesis
Molecular Sequence Data
Peptide Synthases - chemistry
peptides
protein⋅thioester
sortase
Staphylococcus aureus - enzymology
Subtilisins - chemistry
protein⋅thioester
click chemistry
peptides
ligation
sortase
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Summary:Protein ligation sorted: SrtA is one of the molecules nature uses to perform chemoselective ligation on amazingly complex protein molecules. Sortase‐mediated ligation (SML) with chemoselective reactions will find a variety of applications in chemistry, biology, and medicine in the near future.
Bibliography:ark:/67375/WNG-LSD1VCJ3-Q
ArticleID:CBIC201402013
istex:D9DEDAB5FC3398BB9DC5475B7FA5261AC438F833
Department of Biotechnology (DBT) and Department of Science and Technology (DST) New Delhi
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201402013