Regional abnormalities of myocardial deformation in patients with hypertrophic cardiomyopathy: correlations with delayed enhancement in cardiac magnetic resonance

• Published in: European journal of heart failure Vol. 11; no. 10; pp. 952 - 957
• Main Authors: Ghio, Stefano, Revera, Miriam, Mori, Francesca, Klersy, Catherine, Raisaro, Arturo, Raineri, Claudia, Serio, Alessandra, Pasotti, Michele, Visconti, Luigi Oltrona
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.10.2009; Oxford University Press
• Subjects: Adult; Aged; Cardiac magnetic resonance; Cardiomyopathy, Hypertrophic - diagnosis; Case-Control Studies; Confidence Intervals; Echocardiography, Doppler - methods; Female; Follow-Up Studies; Gadolinium; Humans; Hypertrophic cardiomyopathy; Image Enhancement - methods; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging - methods; Male; Middle Aged; Myocardium - pathology; Probability; Reference Values; Risk Assessment; Systolic deformation; Tissue-doppler imaging; Ventricular Dysfunction, Left - diagnosis; Hypertrophic cardiomyopathy; Tissue-Doppler imaging; Systolic deformation; Cardiac magnetic resonance
• ISSN: 1388-9842; 1879-0844; 1879-0844
• DOI: 10.1093/eurjhf/hfp122

Aims Hypertrophic cardiomyopathy (HCM) is a genetic disease histologically characterized by a profound disarray of myocardial fibres and by local fibrosis. We sought to characterize regional left ventricular contractility in HCM patients using deformation analysis and to compare it with the presence or absence of delayed enhancement in cardiac magnetic resonance (CMR). Methods and results We studied 58 HCM patients (mean age 41 years, 37 male). The control population comprised 15 normal subjects. Colour tissue-Doppler imaging was acquired in two-dimensional mode from apical four-chamber and two-chamber views; off-line analysis was performed in four basal and four middle left ventricular segments. Gadolinium-enhanced CMR was performed in 36 HCM patients. In HCM patients, peak systolic strain was not uniform across left ventricular segments; differences were not related to site or thickness of the segment analysed. Paradoxically, positive systolic strain values were measured in six middle segments. Delayed CMR enhancement was associated with lower peak systolic strain (P = 0.007). Regional non-uniformities in peak systolic strain were not observed in normal subjects. Conclusion Areas of reduced left ventricular contractility in deformation analysis are associated with delayed CMR enhancement in patients with HCM.