The role of adjuvant treatment in early‐stage oral cavity squamous cell carcinoma: An international collaborative study

• Published in: Cancer Vol. 124; no. 14; pp. 2948 - 2955
• Main Authors: Fridman, Eran, Na'ara, Shorook, Agarwal, Jaiprakash, Amit, Moran, Bachar, Gideon, Villaret, Andrea Bolzoni, Brandao, Jose, Cernea, Claudio R., Chaturvedi, Pankaj, Clark, Jonathan, Ebrahimi, Ardalan, Fliss, Dan M., Jonnalagadda, Sashikanth, Kohler, Hugo F., Kowalski, Luiz P., Kreppel, Matthias, Liao, Chun‐Ta, Patel, Snehal G., Patel, Rajan S., Robbins, K. Thomas, Shah, Jatin P., Shpitzer, Thomas, Yen, Tzu‐Chen, Zöller, Joachim E., Gil, Ziv
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 15.07.2018
• Subjects: Adjuvant therapy; Adult; Aged; Cancer; Chemoradiotherapy, Adjuvant - methods; Disease-Free Survival; Female; Humans; International Cooperation; Kaplan-Meier Estimate; Male; margins; Margins of Excision; Middle Aged; Mouth - pathology; Mouth - surgery; Mouth Neoplasms - mortality; Mouth Neoplasms - pathology; Mouth Neoplasms - therapy; Multivariate analysis; Neoplasm Invasiveness; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - prevention & control; Neoplasm Staging; Oncology; Oral cavity; Patients; Prognosis; Radiation therapy; Radiotherapy, Adjuvant - methods; Retreatment - statistics & numerical data; Retrospective Studies; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck - mortality; Squamous Cell Carcinoma of Head and Neck - pathology; Squamous Cell Carcinoma of Head and Neck - therapy; Survival; oral cavity; margins; survival; squamous cell carcinoma

BACKGROUND Up to half of patients with oral cavity squamous cell carcinoma (OCSCC) have stage I to II disease. When adequate resection is attained, no further treatment is needed; however, re‐resection or radiotherapy may be indicated for patients with positive or close margins. This multicenter stu...