Diabetes duration and obesity matter in autologous mesenchymal stem/stromal cell transplantation in type 2 diabetes patients

In adults, β-cell regeneration (proliferation, neogenesis or transdifferentiation) rarely occurs in a physiological condition. Because of this stagnant nature of β-cells, β-cell mass is not sufficiently recovered once their numbers are severely decreased. Bone marrow is an attractive source of stem...

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Bibliographic Details
Published inJournal of diabetes investigation Vol. 13; no. 2; pp. 230 - 232
Main Authors Lee, Joonyub, Yoon, Kun‐Ho
Format Journal Article
LanguageEnglish
Published Japan John Wiley & Sons, Inc 01.02.2022
John Wiley and Sons Inc
Wiley
Subjects
Autografts
Beta cells
Body mass index
Bone marrow
Bone marrow transplantation
Bone mass
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - therapy
Humans
Hyperglycemia
Immunological tolerance
Insulin resistance
Mesenchymal Stem Cell Transplantation
Mesenchyme
Obesity - complications
Obesity - surgery
Patients
Regenerative medicine
Stem cell transplantation
Transplantation, Autologous
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Summary:In adults, β-cell regeneration (proliferation, neogenesis or transdifferentiation) rarely occurs in a physiological condition. Because of this stagnant nature of β-cells, β-cell mass is not sufficiently recovered once their numbers are severely decreased. Bone marrow is an attractive source of stem cells in future regenerative medicine. Because of its accessibility and immune tolerance when autologously transplanted, bone marrow-derived stem cells can be an ideal source of β-cells for insulinopenic diabetes patients. [...]this study provides valuable information regarding the efficacy and safety of autologous BM-MSC transplantation in type 2 diabetes patients.
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ISSN:2040-1116
2040-1124
DOI:10.1111/jdi.13721